Myocardial fibrosis, the expansion of the cardiac interstitium through deposition of
extracellular matrix proteins, is a common pathophysiologic companion of many different …

Living cells are constantly exposed to mechanical stimuli arising from the surrounding
extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes …

Cardiac fibrosis is a common pathophysiologic companion of most myocardial diseases,
and is associated with systolic and diastolic dysfunction, arrhythmogenesis, and adverse …

Fibrotic remodeling of the heart in response to injury contributes to heart failure, yet
therapies to treat fibrosis remain elusive. Yes-associated protein (YAP) is activated in …

Mitophagy, a mitochondria-specific form of autophagy, removes dysfunctional mitochondria
and is hence an essential process contributing to mitochondrial quality control. PTEN …

Fibrosis is a general term encompassing a plethora of pathologies that span all systems and
is marked by increased deposition of collagen. Injury of variable etiology gives rise to …

Hypertensive cardiac remodeling is characterized by left ventricular hypertrophy and
interstitial fibrosis, which can lead to heart failure with preserved ejection fraction. The Rho …

Cardiovascular disease (CVD) remains the leading cause of death globally, and heart
failure is a major component of CVD-related morbidity and mortality. The development of …

Fibrosis is a hallmark of heart disease independent of etiology and is thought to contribute to
impaired cardiac dysfunction and development of heart failure. However, the underlying …

RhoA (ras homolog family member A) is a small G-protein that transduces intracellular
signaling to regulate a broad range of cellular functions such as cell growth, proliferation …