Carnitine is essential for the transfer of long-chain fatty acids across the inner mitochondrial
membrane for subsequent β-oxidation. It can be synthesized by the body or assumed with …

Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic lipid accumulation in
the absence of excess alcohol intake. NAFLD is the most common chronic liver disease, and …

Background The metabolic basis of Alzheimer disease (AD) is poorly understood, and the
relationships between systemic abnormalities in metabolism and AD pathogenesis are …

Increased glycolysis is considered as a hallmark of cancer. Yet, cancer cell metabolic
reprograming during therapeutic resistance development is under-studied. Here, through …

Non-alcoholic fatty liver disease (NAFLD) is a clinicopathological change characterized by
the accumulation of triglycerides in hepatocytes and has frequently been associated with …

Lipid droplets (LDs) are ubiquitous dynamic organelles that store and supply lipids in all
eukaryotic and some prokaryotic cells for energy metabolism, membrane synthesis, and …

Over the years, the mitochondrial fatty acid β-oxidation (FAO) pathway has been
characterised at the biochemical level as well as the molecular biological level. FAO plays a …

In mammals, liver is a central organ for controlling the metabolic homeostasis for
carbohydrates, lipid, and proteins. Dysregulation of liver functions could lead to the …

Long-chain fatty acids and lipids serve a wide variety of functions in mammalian
homeostasis, particularly in the formation and dynamic properties of biological membranes …

Reprogramming of cellular metabolism is a hallmark of cancer. Cancer cells undergo
metabolic adaptations to maintain tumorigenicity and survive under the attack of immune …