Acute kidney injury occurs with kidney transplantation and too frequently progresses to the
clinical diagnosis of delayed graft function (DGF). Poor kidney function in the first week of …

The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

Macrophages are critical mediators of tissue homeostasis, with the function of tissue
development and repair, but also in defense against pathogens. Tumor-associated …

Delayed graft function is a form of acute renal failure resulting in post-transplantation
oliguria, increased allograft immunogenicity and risk of acute rejection episodes, and …

The aim of this article is to describe the current and potential clinical translation of
pharmacological inhibitors of poly (ADP-ribose) polymerase (PARP) for the therapy of …

The recent clinical availability of the PARP inhibitor olaparib (Lynparza) opens the door for
potential therapeutic repurposing for non‐oncological indications. Considering (a) the …

Myeloperoxidase in kidney disease. In glomerular and tubulointerstitial disease,
polymorphonuclear-and monocyte-derived reactive oxygen species may contribute to …

Acute kidney injury (AKI) causes considerable morbidity and mortality, particularly in the
case of post-cardiac infarction or kidney transplantation; however, the site-specific …

In the past three decades, nitric oxide has been well established as an important bioactive
molecule implicated in regulation of cardiovascular, nervous, and immune systems …

Acute renal failure in the newborn is a common problem and is typically classified as
prerenal, intrinsic renal disease including vascular insults, and obstructive uropathy. In the …