Regulation of the immune response by TGF-β: from conception to autoimmunity and infection
Transforming growth factor β (TGF-β) is a pleiotropic cytokine involved in both suppressive
and inflammatory immune responses. After 30 years of intense study, we have only begun to …
and inflammatory immune responses. After 30 years of intense study, we have only begun to …
TGFβ control of immune responses in cancer: a holistic immuno-oncology perspective
The immune system responds to cancer in two main ways. First, there are prewired
responses involving myeloid cells, innate lymphocytes and innate-like adaptive lymphocytes …
responses involving myeloid cells, innate lymphocytes and innate-like adaptive lymphocytes …
PSMA-targeting TGFβ-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial
V Narayan, JS Barber-Rotenberg, IY Jung, SF Lacey… - Nature medicine, 2022 - nature.com
Chimeric antigen receptor (CAR) T cells have demonstrated promising efficacy, particularly
in hematologic malignancies. One challenge regarding CAR T cells in solid tumors is the …
in hematologic malignancies. One challenge regarding CAR T cells in solid tumors is the …
Immunoregulation by members of the TGFβ superfamily
WJ Chen, P Ten Dijke - Nature Reviews Immunology, 2016 - nature.com
The transforming growth factor-β (TGFβ) superfamily is encoded by 33 genes and includes
TGFβ, bone morphogenetic proteins (BMPs) and activins. Although TGFβ is well recognized …
TGFβ, bone morphogenetic proteins (BMPs) and activins. Although TGFβ is well recognized …
Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as …
RB Holmgaard, DA Schaer, Y Li, SP Castaneda… - … for immunotherapy of …, 2018 - Springer
Background TGFβ signaling plays a pleotropic role in tumor biology, promoting tumor
proliferation, invasion and metastasis, and escape from immune surveillance. Inhibiting …
proliferation, invasion and metastasis, and escape from immune surveillance. Inhibiting …
Ribosome-associated protein quality control
O Brandman, RS Hegde - Nature structural & molecular biology, 2016 - nature.com
Protein synthesis by the ribosome can fail for numerous reasons including faulty mRNA,
insufficient availability of charged tRNAs and genetic errors. All organisms have evolved …
insufficient availability of charged tRNAs and genetic errors. All organisms have evolved …
TGF-β activation and function in immunity
MA Travis, D Sheppard - Annual review of immunology, 2014 - annualreviews.org
The cytokine TGF-β plays an integral role in regulating immune responses. TGF-β has
pleiotropic effects on adaptive immunity, especially in the regulation of effector and …
pleiotropic effects on adaptive immunity, especially in the regulation of effector and …
TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway
Transforming growth factor–β (TGF-β) is a major immunosuppressive cytokine that maintains
immune homeostasis and prevents autoimmunity through its antiproliferative and anti …
immune homeostasis and prevents autoimmunity through its antiproliferative and anti …
Transforming growth factor-β signaling controls the formation and maintenance of gut-resident memory T cells by regulating migration and retention
N Zhang, MJ Bevan - Immunity, 2013 - cell.com
Tissue-resident memory T (Trm) cells represent a population of memory CD8+ T cells that
can act as first responders to local infection. The mechanisms regulating the formation and …
can act as first responders to local infection. The mechanisms regulating the formation and …
TGFβ suppresses CD8+ T cell expression of CXCR3 and tumor trafficking
AJ Gunderson, T Yamazaki, K McCarty, N Fox… - Nature …, 2020 - nature.com
Transforming growth factor beta (TGFβ) is a multipotent immunosuppressive cytokine. TGFβ
excludes immune cells from tumors, and TGFβ inhibition improves the efficacy of cytotoxic …
excludes immune cells from tumors, and TGFβ inhibition improves the efficacy of cytotoxic …