Decades of research have identified genetic factors and biochemical pathways involved in
neurodegenerative diseases (NDDs). We present evidence for the following eight hallmarks …

Microglia activation is observed in various neurodegenerative diseases. Recent advances in
single-cell technologies have revealed that these reactive microglia were with high spatial …

Huntington's disease (HD) is a devastating monogenic neurodegenerative disease
characterized by early, selective pathology in the basal ganglia despite the ubiquitous …

The neuroimmune system is involved in development, normal functioning, aging, and injury
of the central nervous system. Microglia, first described a century ago, are the main …

Microglia, being the resident immune cells of the central nervous system, play an important
role in maintaining tissue homeostasis and contributes towards brain development under …

In neurodegenerative diseases, debris of dead neurons are thought to trigger glia-mediated
neuroinflammation, thus increasing neuronal death. Here we show that the expression of …

Neurodegenerative diseases cause progressive loss of cognitive and/or motor function and
pose major challenges for societies with rapidly aging populations. Human genetics studies …

Microglia play critical roles in brain development, homeostasis, and neurological disorders.
Here, we report that human microglial-like cells (iMGLs) can be differentiated from iPSCs to …

Abstract Changes in gamma oscillations (20–50 Hz) have been observed in several
neurological disorders. However, the relationship between gamma oscillations and cellular …

INTRODUCTION Microglia play essential roles in central nervous system homeostasis and
influence diverse aspects of neuronal function, including refinement of synaptic networks …