The major arteries and veins of the vertebrate circulatory system are formed early in
embryonic development, before the onset of circulation, following de novo aggregation of …

Vascular endothelial growth factors (VEGFs) regulate blood and lymphatic vessel
development and homeostasis. VEGFs are predominantly produced by endothelial …

Normal tables of development are essential for studies of embryogenesis, serving as an
important resource for model organisms, including the frog Xenopus laevis. Xenopus has …

Tube and lumen formation are essential steps in forming a functional vasculature. Despite
their significance, our understanding of these processes remains limited, especially at the …

Vascular development begins when mesodermal cells differentiate into endothelial cells,
which then form primitive vessels. It has been hypothesized that endothelial-specific gene …

The peptide growth factor apelin is the high affinity ligand for the G-protein-coupled receptor
APJ. During embryonic development of mouse and frog, APJ receptor is expressed at high …

Studies with embryonic explants and embryonic stem cells have suggested a role for
Hedgehog (Hh) signaling in hematopoiesis. However, targeted deletion of Hh pathway …

Recent findings strongly suggest that the molecular pathways involved in the development
and function of blood cells are highly conserved among vertebrates and various invertebrate …

Physiologic wound healing is highly dependent on the coordinated functions of vascular and
non-vascular cells. Resolution of tissue injury involves coagulation, inflammation, formation …

The embryonic vasculature forms by the processes of vasculogenesis and angiogenesis.
Angioblasts (endothelial cell precursors) appear to be induced by fibroblast growth factor 2 …