Molecular mechanisms of coronary microvascular endothelial dysfunction in diabetes mellitus: focus on mitochondrial quality surveillance

D Sun, J Wang, S Toan, D Muid, R Li, X Chang, H Zhou - Angiogenesis, 2022 - Springer
Coronary microvascular endothelial dysfunction is both a culprit and a victim of diabetes,
and can accelerate diabetes-related microvascular and macrovascular complications by …

[HTML][HTML] Roles of mitochondrial dynamics and mitophagy in diabetic myocardial microvascular injury

T Wang, X Wang, T Fu, Y Ma, Q Wang, S Zhang… - Cell Stress and …, 2023 - Elsevier
Myocardial microvessels are composed of a monolayer of endothelial cells, which play a
crucial role in maintaining vascular barrier function, luminal latency, vascular tone, and …

[HTML][HTML] Flow pattern–dependent mitochondrial dynamics regulates the metabolic profile and inflammatory state of endothelial cells

SG Hong, J Shin, SY Choi, JC Powers, BM Meister… - JCI insight, 2022 - ncbi.nlm.nih.gov
Endothelial mitochondria play a pivotal role in maintaining endothelial cell (EC)
homeostasis through constantly altering their size, shape, and intracellular localization …

[HTML][HTML] Empagliflozin restores chronic kidney disease–induced impairment of endothelial regulation of cardiomyocyte relaxation and contraction

RP Juni, R Al-Shama, DWD Kuster, J van der Velden… - Kidney international, 2021 - Elsevier
Chronic kidney disease (CKD) promotes development of cardiac abnormalities and is highly
prevalent in patients with heart failure, particularly in those with preserved ejection fraction …

Functional and dynamic mitochondrial damage by chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) mixture in brain endothelial cell lines and rat …

D Kim, Y Shin, EH Kim, Y Lee, S Kim, HS Kim, HC Kim… - Toxicology letters, 2022 - Elsevier
Abstract The mixture of 5-chloro-2-methyl-4-isothiazolin-3-one (CMIT,
chloromethylisothiazolinone) and 2-methyl-4-isothiazolin-3-one (MIT, methylisothiazolinone) …

Aging-induced impairment of vascular function: mitochondrial redox contributions and physiological/clinical implications

EP Tracy, W Hughes, JE Beare, G Rowe… - Antioxidants & Redox …, 2021 - liebertpub.com
Significance: The vasculature responds to the respiratory needs of tissue by modulating
luminal diameter through smooth muscle constriction or relaxation. Coronary perfusion …

VasoTracker, a low-cost and open source pressure myograph system for vascular physiology

PF Lawton, MD Lee, CD Saunter, JM Girkin… - Frontiers in …, 2019 - frontiersin.org
Pressure myography, one of the most commonly used techniques in vascular research,
measures the diameter of isolated, pressurized arteries to assess the functional activity of …

Common methods in mitochondrial research

Y Yin, H Shen - International Journal of Molecular …, 2022 - spandidos-publications.com
Mitochondrial abnormalities are primarily seen in morphology, structure and function. They
can cause damage to organs, including the heart, brain and muscle, by various …

Functional Interaction among KCa and TRP Channels for Cardiovascular Physiology: Modern Perspectives on Aging and Chronic Disease

EJ Behringer, MA Hakim - International Journal of Molecular Sciences, 2019 - mdpi.com
Effective delivery of oxygen and essential nutrients to vital organs and tissues throughout the
body requires adequate blood flow supplied through resistance vessels. The intimate …

Mitochondrial and metabolic adaptations to exercise-induced fluid shear stress in endothelial cells

SG Hong, J Shin, M Aldokhayyil… - Exercise and sport …, 2022 - journals.lww.com
The endothelium is one of the largest organs in the human body (1). In adults, the intricate
network of arteries, veins, and capillaries, when aligned end-to-end, add up to a truly …