Synaptic memory and CaMKII

RA Nicoll, H Schulman - Physiological reviews, 2023 - journals.physiology.org
Ca2+/calmodulin-dependent protein kinase II (CaMKII) and long-term potentiation (LTP)
were discovered within a decade of each other and have been inextricably intertwined ever …

Neural plasticity and behavior–sixty years of conceptual advances

JD Sweatt - Journal of neurochemistry, 2016 - Wiley Online Library
This brief review summarizes 60 years of conceptual advances that have demonstrated a
role for active changes in neuronal connectivity as a controller of behavior and behavioral …

Mechanisms of CaMKII action in long-term potentiation

J Lisman, R Yasuda, S Raghavachari - Nature reviews neuroscience, 2012 - nature.com
Long-term potentiation (LTP) of synaptic strength occurs during learning and can last for
long periods, making it a probable mechanism for memory storage. LTP induction results in …

The molecular basis of CaMKII function in synaptic and behavioural memory

J Lisman, H Schulman, H Cline - Nature Reviews Neuroscience, 2002 - nature.com
Long-term potentiation (LTP) in the CA1 region of the hippocampus has been the primary
model by which to study the cellular and molecular basis of memory. Calcium/calmodulin …

Spatial memory is improved by aerobic and resistance exercise through divergent molecular mechanisms

RC Cassilhas, KS Lee, J Fernandes, MGM Oliveira… - Neuroscience, 2012 - Elsevier
A growing body of scientific evidence indicates that exercise has a positive impact on human
health, including neurological health. Aerobic exercise, which is supposed to enhance …

Autophosphorylation at Thr286 of the α Calcium-Calmodulin Kinase II in LTP and Learning

KP Giese, NB Fedorov, RK Filipkowski, AJ Silva - Science, 1998 - science.org
The calcium-calmodulin–dependent kinase II (CaMKII) is required for hippocampal long-
term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM) …

Synaptic memory requires CaMKII

W Tao, J Lee, X Chen, J Díaz-Alonso, J Zhou… - Elife, 2021 - elifesciences.org
Long-term potentiation (LTP) is arguably the most compelling cellular model for learning and
memory. While the mechanisms underlying the induction of LTP ('learning') are well …

Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity

HK Lee, M Barbarosie, K Kameyama, MF Bear… - Nature, 2000 - nature.com
Bidirectional changes in the efficacy of neuronal synaptic transmission, such as
hippocampal long-term potentiation (LTP) and long-term depression (LTD), are thought to …

KIBRA anchoring the action of PKMζ maintains the persistence of memory

P Tsokas, C Hsieh, RE Flores-Obando, M Bernabo… - Science …, 2024 - science.org
How can short-lived molecules selectively maintain the potentiation of activated synapses to
sustain long-term memory? Here, we find kidney and brain expressed adaptor protein …

Neuronal Ca2+/Calmodulin-Dependent Protein Kinase II: The Role of Structure and Autoregulation in Cellular Function

A Hudmon, H Schulman - Annual review of biochemistry, 2002 - annualreviews.org
▪ Abstract Highly enriched in brain tissue and present throughout the body, Ca2+/calmodulin-
dependent protein kinase II (CaMKII) is central to the coordination and execution of Ca2+ …