Ion channels represent the molecular entities that give rise to the cardiac action potential,
the fundamental cellular electrical event in the heart. The concerted function of these …

Since the first discovery of Kvβ-subunits more than 15 years ago, many more ancillary Kv
channel subunits were characterized, for example, KChIPs, KCNEs, and BKβ-subunits. The …

Kv7 channels are voltage-gated potassium channels encoded by KCNQ genes that have a
considerable physiological impact in many cell types. This reliance upon Kv7 channels for …

Voltage-gated sodium channels (Na V s) are central elements of cellular excitation.
Notwithstanding advances from recent bacterial Na V (BacNa V) structures, key questions …

KCNE1 is a single-span membrane protein that modulates the voltage-gated potassium
channel KCNQ1 (KV7. 1) by slowing activation and enhancing channel conductance to …

Voltage-gated potassium channels are comprised of four subunits, and each subunit has a
pore domain and a voltage-sensing domain (VSD). The four pore domains assemble to form …

Disrupted in schizophrenia 1 (DISC1) is well established as a genetic risk factor across a
spectrum of psychiatric disorders, a role supported by a growing body of biological studies …

Kv7 channels (KCNQ) represent a family of voltage‐gated K+ channels which plays a
prominent role in brain and cardiac excitability. Their physiological importance is …

Studying the etiology of human neurodevelopmental diseases has long been a challenging
task due to the brain's complexity and its limited accessibility. Human pluripotent stem cells …

Ion channels are essential for basic cellular function and for processes including sensory
perception and intercellular communication in multicellular organisms. Voltage‐gated …