Signaling pathways in Parkinson's disease: molecular mechanisms and therapeutic interventions

X Dong-Chen, C Yong, X Yang, ST Chen-Yu… - Signal transduction and …, 2023 - nature.com
Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide, and its treatment remains a big challenge. The pathogenesis of PD may be …

Levodopa-induced dyskinesia in Parkinson's disease: pathogenesis and emerging treatment strategies

DK Kwon, M Kwatra, J Wang, HS Ko - Cells, 2022 - mdpi.com
The most commonly used treatment for Parkinson's disease (PD) is levodopa, prescribed in
conjunction with carbidopa. Virtually all patients with PD undergo dopamine replacement …

[HTML][HTML] Parkinson's disease and its management: part 1: disease entity, risk factors, pathophysiology, clinical presentation, and diagnosis

G DeMaagd, A Philip - Pharmacy and therapeutics, 2015 - ncbi.nlm.nih.gov
Parkinson’s Disease and Its Management - PMC Back to Top Skip to main content NIH NLM
Logo Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation Search …

Apomorphine subcutaneous infusion in patients with Parkinson's disease with persistent motor fluctuations (TOLEDO): a multicentre, double-blind, randomised …

R Katzenschlager, W Poewe, O Rascol… - The Lancet …, 2018 - thelancet.com
Background Subcutaneous apomorphine infusion is a clinically established therapy for
patients with Parkinson's disease with motor fluctuations not optimally controlled by oral …

Parkinson's disease: A review

DM Radhakrishnan, V Goyal - Neurology India, 2018 - journals.lww.com
Parkinson's disease is a common movement disorder seen in neurological practice, but the
diagnosis and management is challenging. The diagnosis is clinical and sometimes difficult …

Parkinson disease

W Poewe, K Seppi, CM Tanner, GM Halliday… - Nature reviews Disease …, 2017 - nature.com
Parkinson disease is the second-most common neurodegenerative disorder that affects 2–
3% of the population≥ 65 years of age. Neuronal loss in the substantia nigra, which causes …

Parkinson's disease

AJ Lees, J Hardy, T Revesz - The Lancet, 2009 - thelancet.com
Parkinson's disease is a common progressive bradykinetic disorder that can be accurately
diagnosed. It is characterised by the presence of severe pars-compacta nigral-cell loss, and …

Summary of the recommendations of the EFNS/MDS‐ES review on therapeutic management of P arkinson's disease

JJ Ferreira, R Katzenschlager… - European journal of …, 2013 - Wiley Online Library
Objective To summarize the 2010 EFNS/MDS‐ES evidence‐based treatment
recommendations for the management of P arkinson's disease (PD). This summary includes …

Apomorphine for Parkinson's disease: efficacy and safety of current and new formulations

F Carbone, A Djamshidian, K Seppi, W Poewe - CNS drugs, 2019 - Springer
Satisfactory management of Parkinson's disease is a challenge that requires a tailored
approach for each individual. In the advanced phase of the disease, patients may …

Rotigotine effects on early morning motor function and sleep in Parkinson's disease: a double‐blind, randomized, placebo‐controlled study (RECOVER)

C Trenkwalder, B Kies, M Rudzinska, J Fine… - Movement …, 2011 - Wiley Online Library
In a multinational, double‐blind, placebo‐controlled trial (NCT00474058), 287 subjects with
Parkinson's disease (PD) and unsatisfactory early‐morning motor symptom control were …