In spite of promising preclinical results there is a decreasing number of new registered
medications in major depression. The main reason behind this fact is the lack of confirmation …

Multimorbidity, the simultaneous presence of multiple chronic conditions, is an increasing
global health problem and research into its determinants is of high priority. We used …

Effective coordination of the biological stress response is integral for the behavioural well‐
being of an organism. Stress reactivity is coordinated by an interplay of the neuroendocrine …

The heterogeneity and complexity of symptom presentation, comorbidities and genetic
factors pose challenges to the identification of biological mechanisms underlying complex …

Objectives To investigate whether the association between subjective wellbeing (subjective
happiness and life satisfaction) and cardiometabolic health is causal. Design Two sample …

Background Cortisol, a steroid hormone frequently used as a biomarker of stress, is
associated with cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). To …

Background Depression is a psychiatric disorder with a high comorbidity burden; however,
previous comorbidity studies predominately focused on a few common diseases and relied …

Objectives Patients with chronic migraine (CM) display a considerable amount of
comorbidities, particularly psychiatric and cardiovascular, and the presence of multiple …

Purpose Slow gait speed in older adults is associated with increased risk for falls and
fractures, functional dependence, multimorbidity, and even mortality. The risk of these …

Background The comorbidity of obesity and major depressive disorder (MDD) may be
attributable to a bidirectional relationship and shared genetic influence. We aimed to …