Boolean network models are one of the simplest models to study complex dynamic behavior
in biological systems. They can be applied to unravel the mechanisms regulating the …

Molecular mechanisms of health and disease are often represented as systems biology
diagrams, and the coverage of such representation constantly increases. These static …

Regulatory dependencies in molecular networks are the basis of dynamic behaviors
affecting the phenotypical landscape. With the advance of high throughput technologies, the …

Computational modeling has emerged as a critical tool in investigating the complex
molecular processes involved in biological systems and diseases. In this study, we apply …

The dynamics of cellular mechanisms can be investigated through the analysis of networks.
One of the simplest but most popular modeling strategies involves logic-based models …

The interplay between nutrient-induced signaling and metabolism plays an important role in
maintaining homeostasis and its malfunction has been implicated in many different human …

Animals exhibit remarkable feats of behavioral flexibility and multifunctional control that
remain challenging for robotic systems. The neural and morphological basis of …

Hematopoietic stem cells (HSCs) provide all types of blood cells during the entire life of the
organism. HSCs are mainly quiescent and can eventually enter the cell cycle to differentiate …

For many biological systems, a variety of simulation models exist. A new simulation model is
rarely developed from scratch, but rather revises and extends an existing one. A key …

Dendritic cells (DCs) are professional antigen-presenting cells (APCs) with the unique ability
to mediate inflammatory responses of the immune system. Given the critical role of DCs in …