Executive summary The past six decades have seen remarkable improvements in health
outcomes for people with cystic fibrosis, which was once a fatal disease of infants and young …

Advances in anion transport by synthetic supramolecular systems are discussed in this
article. Developments in the design of discrete molecular carriers for anions and …

This comprehensive State of the Art review summarizes the current published knowledge
base regarding the pathophysiology and microbiology of pulmonary disease in cystic …

Deletion of phenylalanine 508 of the cystic fibrosis transmembrane conductance regulator (∆
F508 CFTR) is the major cause of cystic fibrosis, one of the most common inherited …

Cystic fibrosis (CF) remains the most common fatal hereditary lung disease. The discovery of
the cystic fibrosis transmembrane conductance regulator (CFTR) gene 25 years ago set the …

Mutations in the gene coding for the cystic fibrosis transmembrane conductance regulator
(CFTR) epithelial anion channel cause cystic fibrosis (CF). The multidomain integral …

Secretory diarrhea is the leading cause of infant death in developing countries and a major
cause of morbidity in adults. The cystic fibrosis transmembrane conductance regulator …

Chloride channels represent a relatively under-explored target class for drug discovery as
elucidation of their identity and physiological roles has lagged behind that of many other …

Over the past 30 years, a range of cystic fibrosis (CF) animal models have been generated
for research purposes. Different species, including mice, rats, ferrets, rabbits, pigs, sheep …

Cystic fibrosis (CF) is caused by loss-of-function mutations in the CF transmembrane
conductance regulator (CFTR) protein, a cAMP-regulated anion channel expressed …