Mitochondrial dysfunction characterized by impaired bioenergetics, oxidative stress and
aldehydic load is a hallmark of heart failure. Recently, different research groups have …

The intact heart undergoes complex and multiscale remodelling processes in response to
altered mechanical cues. Remodelling of the myocardium is regulated by a combination of …

The heart is vital for biological function in almost all chordates, including humans. It beats
continually throughout our life, supplying the body with oxygen and nutrients while removing …

Abstract Purpose of Review In highly prevalent cardiac diseases, new therapeutic
approaches are needed. Since the first description of oxidative stress in heart failure …

In diabetic patients, cardiomyopathy is an important cause of heart failure, but its
pathophysiology has not been completely understood thus far. Myocardial hypertrophy and …

Cardiac excitation‐contraction (E‐C) coupling is influenced by (at least) three dynamic
systems that couple and feedback to one another (see Abstract Figure). Here we review the …

Junctional membrane complexes facilitate excitation-contraction coupling in skeletal and
cardiac muscle cells by forming subcellular invaginations that maintain close (≤ 20 nm) …

Ca2+ plays a central role in the contraction of the heart. It is the bi-directional link between
electrical excitation of the heart and contraction. Electrical excitation initiates Ca2+ influx …

Myocardial stretch physiologically activates NADPH oxidase 2 (NOX2) to increase reactive
oxygen species (ROS) production. Although physiological low‐level ROS are known to be …

Friedreich's Ataxia (FRDA) is a neurodegenerative disorder, characterized by degeneration
of dorsal root ganglia, cerebellum and cardiomyopathy. Heart failure is one of the most …