The diagnosis of GH deficiency (GHD) in childhood is a multistep process involving clinical
history, examination with detailed auxology, biochemical testing, and pituitary imaging, with …

The anterior pituitary gland has the ability to respond to complex signals derived from central
and peripheral systems. Perception of these signals and their integration are mediated by …

Dopaminergic (DA) signaling governs the control of complex behaviors, and its deregulation
has been implicated in a wide range of diseases. Here we demonstrate that inactivation of …

Dopamine (DA) D2 receptors expressed in DA neurons (D2 autoreceptors) exert a negative
feedback regulation that reduces DA neuron firing, DA synthesis and DA release. As D2 …

Mutations of the parkin gene are the most frequent cause of early onset autosomal recessive
parkinsonism (EO-AR). Here we show that inactivation of the parkin gene in mice results in …

Mammalian life span can be extended by both calorie restriction (CR) and mutations that
diminish somatotropic signaling. Sirt1 is a mediator of many effects of CR in mammals, but …

The relationship between antidopaminergic drugs and glucose has not been extensively
studied, even though chronic neuroleptic treatment causes hyperinsulinemia in normal …

Although long-studied in the central nervous system, there is increasing evidence that
dopamine (DA) has important roles in the periphery including in metabolic regulation. Insulin …

Background Minor alleles of the human dopamine receptor polymorphisms, DRD2/TaqI A
and DRD4/48 bp, are related to decreased functioning and/or numbers of their respective …

Gap junctions are intercellular protein channels which provide a pathway for the exchange
of ions and small molecules. This exchange of materials allows metabolic coupling of cells …