Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease
progression leads to joint deformity and associated loss of function, which significantly …

Matricellular proteins are responsible for regulating the microenvironment, the behaviors of
surrounding cells, and the homeostasis of tissues. Periostin (POSTN), a non-structural …

Cigarette smoke is a complex aerosol containing a large number of compounds with a
variety of toxicity and carcinogenicity. Long-term exposure to cigarette smoke significantly …

Abstract Fibroblast growth factor 19 (FGF19) has appeared as a new possible avenue in the
treatment of skeletal metabolic disorders. However, the role of FGF19 on cell cycle …

Eryptosis is a regulated cell death (RCD) of mature erythrocytes initially described as a
counterpart of apoptosis for enucleated cells. However, over the recent years, a growing …

The crescent presence of nanoplastics in the environment raises concerns regarding their
potential impact on health. This study exposed human colon adenocarcinoma cells (HT29) …

Protein–protein interactions (PPIs) regulate signalling pathways and cell phenotypes, and
the visualization of spatially resolved dynamics of PPIs would thus shed light on the …

Despite significant advances in developing selective JAK2 inhibitors, JAK2 kinase inhibitor
(TKI) therapy is ineffective in suppressing the disease. Reactivation of compensatory MEK …

Identifying oncological applications for drugs that are already approved for other medical
indications is considered a possible solution for the increasing costs of cancer treatment …

SLC7A11 is a unit of the glutamate cystine antiporter Xc− system. It functions to import
cystine for glutathione biosynthesis and maintains the redox balance in cells. Sorafenib …