Mucus-inspired dynamic hydrogels: Synthesis and future perspectives

R Bej, R Haag - Journal of the American Chemical Society, 2022 - ACS Publications
Mucus hydrogels at biointerfaces are crucial for protecting against foreign pathogens and for
the biological functions of the underlying cells. Since mucus can bind to and host both …

Nano-fats for bugs: The benefits of lipid nanoparticles for antimicrobial therapy

CR Thorn, N Thomas, BJ Boyd… - Drug Delivery and …, 2021 - Springer
Bacterial infections are an imminent global healthcare threat evolving from rapidly
advancing bacterial defence mechanisms that antibiotics fail to overcome. Antibiotics have …

Mucus penetration of surface-engineered nanoparticles in various pH microenvironments

Y Guo, Y Ma, X Chen, M Li, X Ma, G Cheng, C Xue… - ACS …, 2023 - ACS Publications
The penetration behavior of nanoparticles in mucous depends on physicochemical
properties of the nanoparticles and the mucus microenvironment, due to particle–mucin …

pH-Mediated mucus penetration of zwitterionic polydopamine-modified silica nanoparticles

Y Ma, Y Guo, S Liu, Y Hu, C Yang, G Cheng, C Xue… - Nano Letters, 2023 - ACS Publications
Zwitterionic polymers have emerged as promising trans-mucus nanocarriers due to their
superior antifouling properties. However, for pH-sensitive zwitterionic polymers, the effect of …

Mucin biopolymers and their barrier function at airway surfaces

D Song, D Cahn, GA Duncan - Langmuir, 2020 - ACS Publications
In the lung, the airway epithelium produces secreted and tethered mucin biopolymers to
form a mucus hydrogel layer and a surface-attached polymer brush layer. These layers work …

Models using native tracheobronchial mucus in the context of pulmonary drug delivery research: composition, structure and barrier properties

BC Huck, X Murgia, S Frisch, M Hittinger… - Advanced Drug Delivery …, 2022 - Elsevier
Mucus covers all wet epithelia and acts as a protective barrier. In the airways of the lungs,
the viscoelastic mucus meshwork entraps and clears inhaled materials and efficiently …

Chitooligosaccharide reconstitutes intestinal mucus layer to improve oral absorption of water-soluble drugs

Y Qi, M Jin, Q Li, Q Wu, Z Liao, M Wei, X Fan… - Journal of Controlled …, 2023 - Elsevier
Intestinal mucus is a complex natural hydrogel barrier with unique physical properties that
impede the absorption of various oral drugs. Both washout from the upper water layer and …

An overview of gastrointestinal mucus rheology under different pH conditions and introduction to pH-dependent rheological interactions with PLGA and chitosan …

G Ruiz-Pulido, DI Medina - European Journal of Pharmaceutics and …, 2021 - Elsevier
This review discusses the physicochemical and mechanical properties of porcine
gastrointestinal mucus from a rheological point of view. Considering mucus as a viscoelastic …

[HTML][HTML] Physiological properties, composition and structural profiling of porcine gastrointestinal mucus

V Barmpatsalou, IR Dubbelboer, A Rodler… - European Journal of …, 2021 - Elsevier
The gastrointestinal mucus is a hydrogel that lines the luminal side of the gastrointestinal
epithelium, offering barrier protection from pathogens and lubrication of the intraluminal …

[HTML][HTML] Gastrointestinal mucus in dog: Physiological characteristics, composition, and structural properties

IR Dubbelboer, V Barmpatsalou, A Rodler… - European Journal of …, 2022 - Elsevier
Gastrointestinal (GI) mucus is continuously secreted and lines the entire length of the GI
tract. Essential for health, it keeps the noxious luminal content away from the epithelium. Our …