Membrane proteins play a most important part in metabolism, signaling, cell motility,
transport, development, and many other biochemical and biophysical processes which …

Many scientific fields, although driven by similar purposes and dealing with similar
technologies, often appear so isolated and far from each other that even the vocabularies to …

Designing molecules for drugs has been a hot topic for many decades. However, it is hard
and expensive to find a new molecule. Thus, the cost of the final drug is also increased …

The intensive use of pesticides has led to their increasing presence in water, soil, and
agricultural products. Mounting evidence indicates that some pesticides may be endocrine …

Abstract Cytochrome P450 (P450, CYP) 19A1 is the steroid aromatase, the enzyme
responsible for the 3‐step conversion of androgens (androstenedione or testosterone) to …

Pesticides are widely applied all over the world, and pesticide exposure can induce different
biological effects posing a possible threat to human health. Due to their effects on the …

Infrared spectroscopy has brought invaluable information about proteins and about the
mechanism of action of enzymes. These achievements are difficult to transpose to living …

Aromatase (CYP19A1), the enzyme that converts androgens to estrogens, is of significant
mechanistic and therapeutic interest. Crystal structures and computational studies of this …

Aromatase is the cytochrome P450 enzyme converting androgens into estrogen in the last
phase of steroidogenesis. As estrogens are crucial in reproductive biology, aromatase is …

Human aromatase is the cytochrome P450 catalyzing the conversion of androgens into
estrogens in a three steps reaction essential to maintain steroid hormones balance. Here we …