The good, the bad, and the ugly–controlling singlet oxygen through design of photosensitizers and delivery systems for photodynamic therapy

S Callaghan, MO Senge - Photochemical & photobiological sciences, 2018 - pubs.rsc.org
Singlet oxygen, although integral to photodynamic therapy, is notoriously uncontrollable,
suffers from poor selectivity and has fast decomposition rates in biological media. Across the …

Click and photo-unclick chemistry of aminoacrylate for visible light-triggered drug release

M Bio, G Nkepang, Y You - Chemical Communications, 2012 - pubs.rsc.org
“Click and Photo-unclick Chemistry” of aminoacrylates is proposed for a new photo-labile
linker. Adducts are built in 2 steps with good yields and cleaved rapidly by tissue penetrable …

Targeting photochemical scalpels or lancets in the photodynamic therapy field—the photochemist's role

S Protti, A Albini, R Viswanathan… - Photochemistry and …, 2017 - Wiley Online Library
This review covers photochemical approaches aimed at supplementing surgical instruments
with handheld photodynamic therapy (PDT) instruments. PDT is not widely used in hospitals …

Folate receptor-mediated enhanced and specific delivery of far-red light-activatable prodrugs of combretastatin A-4 to FR-positive tumor

G Nkepang, M Bio, P Rajaputra, SG Awuah… - Bioconjugate …, 2014 - ACS Publications
We examined the concept of a novel prodrug strategy in which anticancer drug can be
locally released by visible/near IR light, taking advantage of the photodynamic process and …

Far-red light activatable, multifunctional prodrug for fluorescence optical imaging and combinational treatment

M Bio, P Rajaputra, G Nkepang… - Journal of medicinal …, 2014 - ACS Publications
We recently developed “photo-unclick chemistry”, a novel chemical tool involving the
cleavage of aminoacrylate by singlet oxygen, and demonstrated its application to visible …

Efficient activation of a visible light-activatable CA4 prodrug through intermolecular photo-unclick chemistry in mitochondria

M Bio, P Rajaputra, I Lim, P Thapa… - Chemical …, 2017 - pubs.rsc.org
Photo-unclick chemistry mediates visible and near IR-controlled drug release via a singlet
oxygen (SO)-cleavable linker. Due to the limited diffusion distance of SO in biological …

Fluorine end-capped optical fibers for photosensitizer release and singlet oxygen production

D Bartusik, D Aebisher, G Ghosh… - The Journal of Organic …, 2012 - ACS Publications
The usefulness of a fiber optic technique for generating singlet oxygen and releasing the
pheophorbide photosensitizer has been increased by the fluorination of the porous Vycor …

A fiberoptic (photodynamic therapy type) device with a photosensitizer and singlet oxygen delivery probe tip for ovarian cancer cell killing

D Bartusik, D Aebisher, A Ghogare… - Photochemistry and …, 2013 - Wiley Online Library
A portable “fiber optic‐based sensitizer delivery”(FOSD) device has been developed and
studied. Before there might be success in photodynamic therapy (PDT) and antibacterial …

Generating singlet oxygen bubbles: A new mechanism for gas–liquid oxidations in water

D Bartusik, D Aebisher, BB Ghafari, AM Lyons… - Langmuir, 2012 - ACS Publications
Laser-coupled microphotoreactors were developed to bubble singlet oxygen [1O2 (1Δg)]
into an aqueous solution containing an oxidizable compound. The reactors consisted of …

Photoactive fluoropolymer surfaces that release sensitizer drug molecules

G Ghosh, M Minnis, AA Ghogare… - The Journal of …, 2015 - ACS Publications
We describe a physical–organic study of two fluoropolymers bearing a photoreleasable
PEGylated photosensitizer that generates 1O2 (1Δg)[chlorin e6 methoxy tri (ethylene glycol) …