[HTML][HTML] Immunopathogenesis and treatment of cytokine storm in COVID-19
JS Kim, JY Lee, JW Yang, KH Lee, M Effenberger… - Theranostics, 2021 - ncbi.nlm.nih.gov
Abstract Severe coronavirus disease 2019 (COVID-19) is characterized by systemic hyper-
inflammation, acute respiratory distress syndrome, and multiple organ failure. Cytokine …
inflammation, acute respiratory distress syndrome, and multiple organ failure. Cytokine …
Recommendations for the management of hemophagocytic lymphohistiocytosis in adults
Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory syndrome
induced by aberrantly activated macrophages and cytotoxic T cells. The primary (genetic) …
induced by aberrantly activated macrophages and cytotoxic T cells. The primary (genetic) …
Pathophysiology of SARS-CoV-2: the Mount Sinai COVID-19 autopsy experience
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated clinical
syndrome COVID-19 are causing overwhelming morbidity and mortality around the globe …
syndrome COVID-19 are causing overwhelming morbidity and mortality around the globe …
Humoral immune mechanisms involved in protective and pathological immunity during COVID-19
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing COVID-19 is
associated with excessive inflammation, as a main reason for severe condition and death …
associated with excessive inflammation, as a main reason for severe condition and death …
Hemophagocytic lymphohistiocytosis
Context.—Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening disorder of
immune regulation that can eventually result in end-organ damage and death. HLH is …
immune regulation that can eventually result in end-organ damage and death. HLH is …
Reigniting hope in cancer treatment: the promise and pitfalls of IL-2 and IL-2R targeting strategies
S Muhammad, T Fan, Y Hai, Y Gao, J He - Molecular Cancer, 2023 - Springer
Abstract Interleukin-2 (IL-2) and its receptor (IL-2R) are essential in orchestrating immune
responses. Their function and expression in the tumor microenvironment make them …
responses. Their function and expression in the tumor microenvironment make them …
T-cell activation profiles distinguish hemophagocytic lymphohistiocytosis and early sepsis
V Chaturvedi, RA Marsh, A Zoref-Lorenz… - Blood, The Journal …, 2021 - ashpublications.org
Hemophagocytic lymphohistiocytosis (HLH) is a fatal disorder of immune hyperactivation
that has been described as a cytokine storm. Sepsis due to known or suspected infection …
that has been described as a cytokine storm. Sepsis due to known or suspected infection …
Recommendations for the use of etoposide-based therapy and bone marrow transplantation for the treatment of HLH: consensus statements by the HLH Steering …
S Ehl, I Astigarraga, T von Bahr Greenwood… - The Journal of Allergy …, 2018 - Elsevier
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory
syndrome requiring aggressive immunosuppressive therapy. Following 2 large international …
syndrome requiring aggressive immunosuppressive therapy. Following 2 large international …
Comparative survival analysis of immunomodulatory therapy for coronavirus disease 2019 cytokine storm
S Narain, DG Stefanov, AS Chau, AG Weber, G Marder… - Chest, 2021 - Elsevier
Background Cytokine storm is a marker of coronavirus disease 2019 (COVID-19) illness
severity and increased mortality. Immunomodulatory treatments have been repurposed to …
severity and increased mortality. Immunomodulatory treatments have been repurposed to …
Hemophagocytic lymphohistiocytosis in critically ill patients: diagnostic reliability of HLH-2004 criteria and HScore
C Knaak, P Nyvlt, FS Schuster, C Spies, P Heeren… - Critical Care, 2020 - Springer
Background Hemophagocytic lymphohistiocytosis (HLH) is a rare though often fatal
hyperinflammatory syndrome mimicking sepsis in the critically ill. Diagnosis relies on the …
hyperinflammatory syndrome mimicking sepsis in the critically ill. Diagnosis relies on the …