Ferroptosis is a new kind of regulated cell death that is characterized by highly iron-
dependent lipid peroxidation. Ferroptosis involves various biology processes, such as iron …

Iron is an essential mineral required for a variety of vital biological functions. Despite being
vital for life, iron also has potentially toxic aspects. Iron has been investigated as a risk factor …

Aims Whether and how iron affects the progression of atherosclerosis remains highly
debated. Here, we investigate susceptibility to atherosclerosis in a mouse model (ApoE …

Ferroptosis, a newly discovered form of regulatory cell death (RCD), has been demonstrated
to be distinct from other types of RCD, such as apoptosis, necroptosis, and autophagy …

Chronic heart failure is the end stage of cardiac diseases. With a high prevalence and a high
mortality rate worldwide, chronic heart failure is one of the heaviest health-related burdens …

Atherosclerotic cardiovascular disease is a major burden on global health and a leading
cause of death worldwide. The pathophysiology of this chronic disease is complex, involving …

Chronic kidney disease (CKD) is recognised as a health concern globally and leads to high
rates of morbidity, mortality and healthcare expenditure. CKD is itself an independent risk …

Iron accumulates in human atherosclerotic lesions but whether it is a cause or simply a
downstream consequence of the atheroma formation has been an open question for …

Significance: While atherosclerosis is an almost inevitable consequence of aging, food
preferences, lack of exercise, and other aspects of the lifestyle in many countries, the …

Throughout life, macrophages are located in every tissue of the body, where their main roles
are to phagocytose cellular debris and recycle aging red blood cells. In the tissue niche, they …