Circadian clocks respond to environmental time cues to coordinate 24-hour oscillations in
almost every tissue of the body. In the breast, circadian clocks regulate the rhythmic …

Inverse comorbidity is a lower-than-expected probability of disease occuring in individuals
who have been diagnosed with other medical conditions. Emerging evidence points to …

Breast cancer is the most common type of cancer worldwide and one of the major causes of
cancer death in women. Epidemiological studies have established a link between night-shift …

Several studies suggest a link between circadian rhythm disturbances and tumorigenesis.
However, the association between circadian clock genes and prognosis in breast cancer …

Posttranslational modifications play central roles in myriad biological pathways including
circadian regulation. We employed a circadian proteomic approach to demonstrate that …

The clock gene machinery controls cellular metabolism, proliferation, and key functions,
such as DNA damage recognition and repair. Dysfunction of the circadian clock is involved …

To identify new tumor‐suppressor gene candidates relevant for human
hepatocarcinogenesis, we performed genome‐wide methylation profiling and vertical …

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death due to its
early recurrence and widespread metastatic potential. Accumulating studies have reported …

Background Fatigue and sleep problems are prevalent in cancer patients and can be
associated with disruption of circadian rhythmicity. In this prospective phase II trial, we …

The circadian clock gene Period2 (PER2) has been suggested to be a tumor suppressor.
However, detailed mechanistic evidence has not been provided to support this hypothesis …