Neural Circuits Underlying Behavioral Flexibility: Insights From Drosophila

AV Devineni, KM Scaplen - Frontiers in Behavioral Neuroscience, 2022 - frontiersin.org
Behavioral flexibility is critical to survival. Animals must adapt their behavioral responses
based on changes in the environmental context, internal state, or experience. Studies in …

Interactions and toxicity of non-essential heavy metals (Cd, Pb and Hg): lessons from Drosophila melanogaster

KD Fasae, AO Abolaji - Current opinion in insect science, 2022 - Elsevier
Highlights•Drosophila is a useful model to study interactions of non-essential heavy
metals.•Cd, Pb, and Hg reduce the development of Drosophila.•Cd, Pb, and Hg induce …

N6-adenosine methylation controls the translation of insulin mRNA

D Wilinski, M Dus - Nature Structural & Molecular Biology, 2023 - nature.com
Control of insulin mRNA translation is crucial for energy homeostasis, but the mechanisms
remain largely unknown. We discovered that insulin mRNAs across invertebrates …

[HTML][HTML] Context-dependent control of behavior in Drosophila

TB Oram, GM Card - Current Opinion in Neurobiology, 2022 - Elsevier
The representation of contextual information peripheral to a salient stimulus is central to an
animal's ability to correctly interpret and flexibly respond to that stimulus. While the …

The diet-microbiome tango: how nutrients lead the gut brain axis

G Ezra-Nevo, SF Henriques, C Ribeiro - Current Opinion in Neurobiology, 2020 - Elsevier
Highlights•Dietary nutrients are important modulators of brain function and behavior.•The
microbiome shapes brain function by altering the nutrient content of the diet and producing …

Obesity-induced taste dysfunction, and its implications for dietary intake

F Harnischfeger, R Dando - International Journal of Obesity, 2021 - nature.com
The incidence of obesity has dramatically increased in recent years, and poses a public
health challenge for which an effective and scalable intervention strategy is yet to be found …

[HTML][HTML] Impact of dietary sucrose on adiposity and glucose homeostasis in C57BL/6J mice depends on mode of ingestion: liquid or solid

J Togo, S Hu, M Li, C Niu, JR Speakman - Molecular metabolism, 2019 - Elsevier
Objective Although it is widely accepted that obesity results from an imbalance of energy
intake and expenditure, the mechanisms underlying this process and effective strategies for …

A nexus of lipid and O-Glcnac metabolism in physiology and disease

A Lockridge, JA Hanover - Frontiers in Endocrinology, 2022 - frontiersin.org
Although traditionally considered a glucose metabolism-associated modification, the O-
linked β-N-Acetylglucosamine (O-GlcNAc) regulatory system interacts extensively with lipids …

The neuroscience of sugars in taste, gut-reward, feeding circuits, and obesity

R Gutierrez, E Fonseca, SA Simon - Cellular and Molecular Life Sciences, 2020 - Springer
Throughout the animal kingdom sucrose is one of the most palatable and preferred tastants.
From an evolutionary perspective, this is not surprising as it is a primary source of energy …

Taste cells expressing Ionotropic Receptor 94e reciprocally impact feeding and egg laying in Drosophila

J Guillemin, J Li, V Li, SAT McDowell, K Audette… - Cell Reports, 2024 - cell.com
Chemosensory cells across the body of Drosophila melanogaster evaluate the environment
to prioritize certain behaviors. Previous mapping of gustatory receptor neurons (GRNs) on …