Validation of in-vitro bioassay methods: Application in herbal drug research

G Indrayanto, GS Putra, F Suhud - Profiles of drug substances, excipients …, 2021 - Elsevier
This present review described the validation method of in-vitro bioassay for its application in
herbal drug research. Seven sequencing steps that can be taken for performing a valid …

Interactions between medical plant-derived bioactive compounds: focus on antimicrobial combination effects

N Vaou, E Stavropoulou, C Voidarou, Z Tsakris… - Antibiotics, 2022 - mdpi.com
It is accepted that the medicinal use of complex mixtures of plant-derived bioactive
compounds is more effective than purified bioactive compounds due to beneficial …

Expanding the chemical diversity through microorganisms co-culture: Current status and outlook

D Arora, P Gupta, S Jaglan, C Roullier, O Grovel… - Biotechnology …, 2020 - Elsevier
Natural products (NPs) are considered as a cornerstone for the generation of bioactive leads
in drug discovery programs. However, one of the major limitations of NP drug discovery …

NP analyst: an open online platform for compound activity mapping

S Lee, JA van Santen, N Farzaneh, DY Liu… - ACS Central …, 2022 - ACS Publications
Few tools exist in natural products discovery to integrate biological screening and
untargeted mass spectrometry data at the library scale. Previously, we reported Compound …

Therapeutic effects and molecular mechanisms of bioactive compounds against respiratory diseases: traditional Chinese medicine theory and high-frequency use

J Wang, Q Wu, L Ding, S Song, Y Li, L Shi… - Frontiers in …, 2021 - frontiersin.org
Respiratory diseases, especially the pandemic of respiratory infectious diseases and
refractory chronic lung diseases, remain a key clinical issue and research hot spot due to …

Use of the versatility of fungal metabolism to meet modern demands for healthy aging, functional foods, and sustainability

JA Takahashi, BVR Barbosa, BA Martins… - Journal of Fungi, 2020 - mdpi.com
Aging-associated, non-transmissible chronic diseases (NTCD) such as cancer,
dyslipidemia, and neurodegenerative disorders have been challenged through several …

Promising natural products in crop protection and food preservation: Basis, advances, and future prospects

TA Ogunnupebi, AP Oluyori, AO Dada… - … Journal of Agronomy, 2020 - Wiley Online Library
The increase in demand for agricultural produce necessitates the continuous search for
affordable, ecofriendly, readily available crop protectors, and food preservatives. Historically …

nanoRAPIDS as an analytical pipeline for the discovery of novel bioactive metabolites in complex culture extracts at the nanoscale

I Nuñez Santiago, NV Machushynets… - Communications …, 2024 - nature.com
Microbial natural products form the basis of most of the antibiotics used in the clinic. The vast
majority has not yet been discovered, among others because the hidden chemical space is …

Practical guide toward discovery of biomolecules with biostimulant activity

J Li, R Lardon, S Mangelinckx… - Journal of Experimental …, 2024 - academic.oup.com
The growing demand for sustainable solutions in agriculture, critical for crop productivity and
food quality in the face of climate change and reduced agrochemical usage, has brought …

Combining the Strengths of MS and NMR in Biochemometrics: A Case Study on Buddleja officinalis

A Wasilewicz, A Areesanan, B Kirchweger… - Journal of Natural …, 2024 - ACS Publications
Biochemometrics has emerged as promising strategy for the targeted identification of
bioactive constituents from natural sources. It is based on the correlation of bioactivity data …