Immune responses need to be controlled for optimal protective immunity and tolerance.
Coinhibitory pathways in the B7-CD28 family provide critical inhibitory signals that regulate …

B Lymphocytes and Cancer: A Love–Hate Relationship: Trends in Cancer Skip to Main Content
Advertisement Trends in Cancer This journal offers authors two options (open access or …

Nanomaterials and targeted drug delivery vehicles improve the therapeutic index of drugs
and permit greater control over their pharmacokinetics, biodistribution, and bioavailability …

Hypophysitis is a chronic inflammation of the pituitary gland of unknown (primary forms) or
recognizable (secondary forms) etiology, such as the use of ipilimumab in cancer …

The immune response consists of a finely-tuned program, the activation of which must be
coupled with inhibitory mechanisms whenever initiated. This ensures tight control of …

Tumors can avoid immune surveillance by stimulating immune inhibitory receptors that
function to turn off established immune responses. By blocking the ability of tumors to …

Within the paradigm of the two-signal model of lymphocyte activation, the interest in
costimulation has witnessed a remarkable emergence in the past few years with the …

Immunoglobulin E (IgE) isotype antibodies are associated with atopic disease, namely
allergic rhinitis, asthma and atopic dermatitis, but are also involved in host immune defence …

Immune responses must be tightly regulated to ensure both optimal protective immunity and
tolerance. Costimulatory pathways within the B7: CD28 family provide essential signals for …

Blocking the immune checkpoint molecule CTL antigen-4 (CTLA-4) with ipilimumab has
proven to induce long-lasting clinical responses in patients with metastatic melanoma. To …