Ion channels are integral membrane proteins whose gating has been increasingly shown to
depend on the presence of the low-abundance membrane phospholipid …

Rapidly activating and inactivating cardiac transient outward K+ currents, Ito, are expressed
in most mammalian cardiomyocytes, and contribute importantly to the early phase of action …

Human mutations in CNTNAP2 are associated with an array of neuropsychiatric and
neurological syndromes, including speech and language disorders, epilepsy, and autism …

Glycogen synthase kinase 3β (GSK3) is a multifaceted serine/threonine (S/T) kinase
expressed in all eukaryotic cells. GSK3β is highly enriched in neurons in the central nervous …

Neurons are highly polarized cells with apparent functional and morphological differences
between dendrites and axon. A critical determinant for the molecular and functional identity …

OBJECTIVE: Multidrug resistance (MDR) in human B-cell lymphoma constitutes a major
obstacle to the effectiveness of chemotherapy. The aim of this study was to investigate the …

Postinhibitory rebound spiking is characteristic of several neuron types and brain regions,
where it sustains spontaneous activity and central pattern generation. However, rebound …

The basic architecture of the voltage-dependent K+ channels (Kv channels) corresponds to
a transmembrane protein core in which the permeation pore, the voltage-sensing …

Huntington's disease (HD) is initially characterized by an inability to suppress unwanted
movements, a deficit attributable to impaired synaptic activation of striatal indirect pathway …

Voltage-gated ion channels are a diverse family of signaling proteins that mediate rapid
electrical signaling events. Among these, voltage-gated potassium or Kv channels are the …