On the role of prolyl oligopeptidase in health and disease

JA García-Horsman, PT Männistö, JI Venäläinen - Neuropeptides, 2007 - Elsevier
Prolyl oligopeptidase (POP) is a serine peptidase which digests small peptide-like
hormones, neuroactive peptides, and various cellular factors. Therefore, this peptidase has …

[HTML][HTML] Development of the retina and optic pathway

BE Reese - Vision research, 2011 - Elsevier
Our understanding of the development of the retina and visual pathways has seen
enormous advances during the past 25years. New imaging technologies, coupled with …

[HTML][HTML] Single-cell transcriptomic comparison of human fetal retina, hPSC-derived retinal organoids, and long-term retinal cultures

A Sridhar, A Hoshino, CR Finkbeiner, A Chitsazan… - Cell reports, 2020 - cell.com
To study the development of the human retina, we use single-cell RNA sequencing (RNA-
seq) at key fetal stages and follow the development of the major cell types as well as …

Regulation of lifespan by neural excitation and REST

JM Zullo, D Drake, L Aron, P O'Hern, SC Dhamne… - Nature, 2019 - nature.com
The mechanisms that extend lifespan in humans are poorly understood. Here we show that
extended longevity in humans is associated with a distinct transcriptome signature in the …

Progressive ganglion cell degeneration precedes neuronal loss in a mouse model of glaucoma

BP Buckingham, DM Inman, W Lambert… - Journal of …, 2008 - Soc Neuroscience
Glaucoma is characterized by retinal ganglion cell (RGC) pathology and a progressive loss
of vision. Previous studies suggest RGC death is responsible for vision loss in glaucoma, yet …

[HTML][HTML] A genomic view of the sea urchin nervous system

RD Burke, LM Angerer, MR Elphick, GW Humphrey… - Developmental …, 2006 - Elsevier
The sequencing of the Strongylocentrotus purpuratus genome provides a unique
opportunity to investigate the function and evolution of neural genes. The neurobiology of …

Distinct ipRGC subpopulations mediate light's acute and circadian effects on body temperature and sleep

AC Rupp, M Ren, CM Altimus, DC Fernandez… - Elife, 2019 - elifesciences.org
The light environment greatly impacts human alertness, mood, and cognition by both acute
regulation of physiology and indirect alignment of circadian rhythms. These processes …

Ikaros confers early temporal competence to mouse retinal progenitor cells

J Elliott, C Jolicoeur, V Ramamurthy, M Cayouette - Neuron, 2008 - cell.com
In the developing mouse retina, multipotent retinal progenitor cells (RPCs) give rise to
specific retinal cell types at different times, but the molecular mechanisms regulating how …

ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells

L Pan, M Deng, X Xie, L Gan - 2008 - journals.biologists.com
LIM-homeodomain (HD) and POU-HD transcription factors play crucial roles in
neurogenesis. However, it remains largely unknown how they cooperate in this process and …

Genomic regulatory networks and animal development

A Stathopoulos, M Levine - Developmental cell, 2005 - cell.com
The synthesis of gene expression data and cis-regulatory analysis permits the elucidation of
genomic regulatory networks. These networks provide a direct visualization of the functional …