Intracellular α-synuclein (α-syn)-rich protein aggregates called Lewy pathology (LP) and
neuronal death are commonly found in the brains of patients with clinical Parkinson disease …

Dysfunctional dopamine (DA) signaling has been associated with a broad spectrum of
neuropsychiatric disorders, prompting investigations into how midbrain DA neuron …

Aging-related, nonresolving inflammation in both the central nervous system (CNS) and
periphery predisposes individuals to the development of neurodegenerative disorders …

Cellular specialization is particularly prominent in mammalian nervous systems, which are
composed of millions to billions of neurons that appear in thousands of different'flavors' and …

Dopamine controls essential brain functions through volume transmission. Different from fast
synaptic transmission, where neurotransmitter release and receptor activation are tightly …

Parkinson's disease (PD) is defined by the loss of dopaminergic neurons in the substantia
nigra and the formation of Lewy body inclusions containing aggregated α-synuclein. Efforts …

Cell senescence has been implicated in the pathology of Parkinson's disease (PD). Both
abnormal α-synuclein aggregation and iron deposition are suggested to be the triggers …

The midbrain dopamine (mDA) system is composed of molecularly and functionally distinct
neuron subtypes that mediate specific behaviours and are linked to various brain diseases …

Monoamine oxidase (MAO) metabolizes cytosolic dopamine (DA), thereby limiting auto-
oxidation, but is also thought to generate cytosolic hydrogen peroxide (H2O2). We show that …

Recent studies across multiple tumour types are starting to reveal a recurrent regulatory
architecture in which genomic alterations cluster upstream of functional master regulator …