[HTML][HTML] Targeting VEGF in eye neovascularization: What's new?: A comprehensive review on current therapies and oligonucleotide-based interventions under …

M Amadio, S Govoni, A Pascale - Pharmacological research, 2016 - Elsevier
Roughly ten years ago the FDA approved most of the presently used anti-VEGF drugs for the
treatment of neovascular AMD and other eye pathologies characterized by ocular …

Intravitreal anti-VEGF agents and cardiovascular risk

M Porta, E Striglia - Internal and emergency medicine, 2020 - Springer
Abstract Antagonists of Vascular Endothelial Growth Factor (Anti-VEGF) are widely
administered by intravitreal injection for the treatment of ocular pathologies such as Age …

WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing

EM Amin, S Oltean, J Hua, MVR Gammons… - Cancer cell, 2011 - cell.com
Angiogenesis is regulated by the balance of proangiogenic VEGF 165 and antiangiogenic
VEGF 165 b splice isoforms. Mutations in WT1, the Wilms' tumor suppressor gene, suppress …

[PDF][PDF] Comprehensive physiology

DK Hamson, MM Roes, LAM Galea, R Terjung - 2016 - open.library.ubc.ca
Sex differences in neurological disease extend from incidence, severity, progression and
symptoms and may ultimately influence treatment. Cognitive disturbances are frequent in …

Vascular endothelial growth factor-A165b is protective and restores endothelial glycocalyx in diabetic nephropathy

S Oltean, Y Qiu, JK Ferguson, M Stevens… - Journal of the …, 2015 - journals.lww.com
Diabetic nephropathy is the leading cause of ESRD in high-income countries and a growing
problem across the world. Vascular endothelial growth factor-A (VEGF-A) is thought to be a …

[HTML][HTML] Mechanisms of glioma formation: iterative perivascular glioma growth and invasion leads to tumor progression, VEGF-independent vascularization, and …

GJ Baker, VN Yadav, S Motsch, C Koschmann… - Neoplasia, 2014 - Elsevier
As glioma cells infiltrate the brain they become associated with various microanatomic brain
structures such as blood vessels, white matter tracts, and brain parenchyma. How these …

Development of potent, selective SRPK1 inhibitors as potential topical therapeutics for neovascular eye disease

J Batson, HD Toop, C Redondo… - ACS chemical …, 2017 - ACS Publications
Serine/arginine-protein kinase 1 (SRPK1) regulates alternative splicing of VEGF-A to pro-
angiogenic isoforms and SRPK1 inhibition can restore the balance of pro/antiangiogenic …

[HTML][HTML] VEGF-A165b is an endogenous neuroprotective splice isoform of vascular endothelial growth factor A in vivo and in vitro

N Beazley-Long, J Hua, T Jehle, RP Hulse… - The American journal of …, 2013 - Elsevier
Vascular endothelial growth factor (VEGF) A is generated as two isoform families by
alternative RNA splicing, represented by VEGF-A 165 a and VEGF-A 165 b. These isoforms …

Systemic dendrimer nanotherapies for targeted suppression of choroidal inflammation and neovascularization in age-related macular degeneration

SP Kambhampati, IA Bhutto, T Wu, K Ho… - Journal of Controlled …, 2021 - Elsevier
Inflammation and neovascularization are key pathological events in human age-related
macular degeneration (AMD). Activated microglia/macrophages (mi/ma) and retinal …

VEGF165b Modulates Endothelial VEGFR1–STAT3 Signaling Pathway and Angiogenesis in Human and Experimental Peripheral Arterial Disease

VC Ganta, M Choi, A Kutateladze, BH Annex - Circulation research, 2017 - Am Heart Assoc
Rationale: Atherosclerotic-arterial occlusions decrease tissue perfusion causing ischemia to
lower limbs in patients with peripheral arterial disease (PAD). Ischemia in muscle induces …