[HTML][HTML] Process analytical technologies–advances in bioprocess integration and future perspectives

G Gerzon, Y Sheng, M Kirkitadze - Journal of pharmaceutical and …, 2022 - Elsevier
Abstract Process Analytical Technology (PAT) instruments include analyzers capable of
measuring physical and chemical process parameters and key attributes with the goal of …

[HTML][HTML] Understanding molecular mechanisms of biologics drug delivery and stability from NMR spectroscopy

P Phyo, X Zhao, AC Templeton, W Xu… - Advanced Drug Delivery …, 2021 - Elsevier
Protein therapeutics carry inherent limitations of membrane impermeability and structural
instability, despite their predominant role in the modern pharmaceutical market. Effective …

An ambient pressure method for synthesizing NaY zeolite

J Wang, M Li, Y Fu, CC Amoo, Y Jiang, R Yang… - Microporous and …, 2021 - Elsevier
Zeolites are vital industrial materials applied widely in the field of heterogeneous catalysis.
Porous zeolites are essentially synthesized in the presence of soft or hard templates in …

Substituent effect of imidazolium ionic liquid: a potential strategy for high coulombic efficiency Al battery

C Yang, S Wang, X Zhang, Q Zhang… - The Journal of …, 2019 - ACS Publications
The chemical structure–effect relationship between imidazolium ion liquid and the properties
of electrolyte or Al battery is first completely revealed. First, it is proved that there indeed …

Quantitative NMR Interpretation without Reference

PI Rubim de Santana… - Journal of Analytical …, 2022 - Wiley Online Library
As has been documented numerous times over the years, nuclear magnetic resonance
(NMR) experiments are intrinsically quantitative. Still, quantitative NMR methods have not …

Using water proton NMR to characterize aluminum-adjuvanted vaccines

KT Briggs, MB Taraban, YB Yu - 2024 - books.rsc.org
Aluminum-adjuvanted vaccines are a major class of prophylactics used to immunize people
against a wide-range of infectious diseases. 1 There are over 30 marketed aluminum …

Structural Fingerprinting of siRNA Therapeutics by Solution NMR Spectroscopy

OB Becette, A Tran, JW Jones, JP Marino… - nucleic acid …, 2022 - liebertpub.com
Nucleic acids are an increasingly popular platform for the development of biotherapeutics to
treat a wide variety of illnesses, including diseases where traditional drug development …

Structural fingerprinting of antisense oligonucleotide therapeutics by solution NMR spectroscopy

OB Becette, JP Marino, RG Brinson - Pharmaceutical Research, 2023 - Springer
Purpose Antisense oligonucleotide (ASO) therapeutics are an emerging class of
biopharmaceuticals to treat and prevent diseases, particularly those involving “undruggable” …

On the utility of nonuniformly sampled two‐dimensional NMR spectra in the pharmaceutical industry

Á Szigetvári, C Szántay Jr - Magnetic Resonance in Chemistry, 2021 - Wiley Online Library
In this work, we discuss representative examples of the application of nonuniform sampling
(NUS) in small‐molecule structure determination in a pharmaceutical research and …

Quantitative 31P NMR Spectroscopy: Principles, Methodologies, and Applications in Phosphorus-Containing Compound Analysis

Y Liu, L Gao, Z Yu - Applied Sciences, 2024 - mdpi.com
Nuclear magnetic resonance (NMR) spectroscopy is gaining prominence as a vital
quantitative method for sample analysis, with significant progress being made in the …