Intrarenal autoregulatory mechanisms maintain renal blood flow (RBF) and glomerular
filtration rate (GFR) independent of renal perfusion pressure (RPP) over a defined range (80 …

Since the discovery of renin as a pressor substance in 1898, the renin-angiotensin (RAS)
system has been extensively studied because it remains a prime candidate as a causative …

The renin-angiotensin system (RAS) is a coordinated hormonal cascade in the control of
cardiovascular, renal, and adrenal function that governs body fluid and electrolyte balance …

Angiotensin II (Ang II), the biologically active component of renin-angiotensin system (RAS),
acts through two receptor subtypes, the AT1 and the AT2 receptor. All classic physiological …

THERE are two major angiotensin II receptor isoforms, AT1 and AT2. AT1 mediates the well-
known pressor and mitogenic effects of angiotensin II (refs 1-5), but the signalling …

The renin angiotensin system (RAS) produced hormone peptides regulate many vital body
functions. Dysfunctional signaling by receptors for RAS peptides leads to pathologic states …

The renin-angiotensin system is a major physiological regulator of body fluid volume,
electrolyte balance, and arterial pressure. Virtually all of the biological actions of the …

Angiotensin II (Ang II) plays an important role in regulating cardiovascular hemodynamics
and structure. Multiple lines of evidence have suggested the existence of Ang II receptor …

Tubular reabsorption of filtered sodium is quantitatively the main contribution of kidneys to
salt and water homeostasis. The transcellular reabsorption of sodium proceeds by a two …

Since the discovery of nonpeptidic ligands, the receptors for angiotensin (Ang) II have been
classified into 2 subtypes (Ang II type 1 receptor [AT1-R] and Ang II type 2 receptor [AT2-R]) …