Abstract MNNG HOS transforming gene (MET) is a class IV receptor tyrosine kinase,
expressed on the surface of epithelial cells. The interaction with the hepatocyte grow factor …

The turnover of endoplasmic reticulum (ER) ensures the correct biological activity of its
distinct domains. In mammalian cells, the ER is degraded via a selective autophagy pathway …

The activation of receptor tyrosine kinases in response to extracellular signals is a principal
component of metazoan signaling. Structural analysis of the extracellular and intracellular …

Probing the oligomeric state of abundant molecules, such as membrane proteins in intact
cells, is essential, but has not been straightforward. We address this challenge with a simple …

Embedding of cell-surface receptors into a membrane defines their dynamics but also
complicates experimental characterization of their signaling complexes. The hepatocyte …

It has long been thought that transmembrane cell‐surface receptors, such as receptor
tyrosine kinases and cytokine receptors, among others, are activated by ligand binding …

Receptor tyrosine kinases (RTKs) are single-pass membrane proteins that control vital cell
processes such as cell growth, survival, and differentiation. There is a growing body of …

Receptor tyrosine kinases (RTKs) orchestrate cell motility and differentiation. Deregulated
RTKs may promote cancer and are prime targets for specific inhibitors. Increasing evidence …

Fluorescence methods are important tools in modern biology. Direct labeling of
biomolecules with a fluorophore might, however, change interaction surfaces. Here, we …

The limit of subdiffraction imaging with fluorescent proteins currently lies at 20 nm, and
therefore most protein complexes are too small (2–5 nm) to spatially resolve their individual …