The Safe-by-Design (SbD) concept aims to facilitate the development of safer
materials/products, safer production, and safer use and end-of-life by performing timely SbD …

The use of Carbon Nanotubes (CNT) and Graphene increased in the last decade and it is
likely to keep increasing in the near future. The attractiveness of their properties, particularly …

Considering the increasing production of engineered nanomaterials (ENMs), new approach
methodologies (NAMs) are essential for safe-by-design approaches and risk assessment …

Introduction: Here, we describe the generation of hypotheses for grouping nanoforms (NFs)
after inhalation exposure and the tailored Integrated Approaches to Testing and Assessment …

The risk of each nanoform (NF) of the same substance cannot be assumed to be the same,
as they may vary in their physicochemical characteristics, exposure and hazard. However …

Nanomaterials (NMs) can be manufactured in plenty of variants differing in their
physicochemical properties. Functional assays can be highly useful to cope with the …

Grouping of substances is a method used to streamline hazard and risk assessment.
Assessment of similarity provides the scientific evidence needed for formation of groups …

Significant advances have been made in the development of Adverse Outcome Pathways
(AOPs) over the last decade, mainly focused on the toxicity mechanisms of chemicals. These …

New registration requirements for nanomaterials under REACH consider the possibility to
form 'sets of similar nanoforms' for a joined human health and environmental hazard …

Understanding the bioaccumulation of engineered nanomaterials (ENMs) is essential for
making regulatory decisions on potential environmental risks. Research in the field of ENM …