Alzheimer's disease (AD) is the most common form of neurodegenerative disorder with
dementia, accounting for approximately 70% of the all cases. Currently, 5.8 million people in …

Glycogen synthase kinase-3 (GSK-3) is a ubiquitously expressed serine/threonine kinase
with a plethora of substrates. As a modulator of several cellular processes, GSK-3 has a …

Abstract Glycogen synthase kinase-3 (GSK3) may be the busiest kinase in most cells, with
over 100 known substrates to deal with. How does GSK3 maintain control to selectively …

Alzheimer's disease (AD) is the foremost type of dementia that afflicts considerable morbidity
and mortality in aged population. Several transcription molecules, pathways, and molecular …

Background: The ARGO study was a phase II, double-blind, placebo controlled, four parallel
arm trial of tideglusib in Alzheimer's disease (AD). Objective: To prove the clinical efficacy of …

Alzheimer's disease (AD) is an age-related devastating neurodegenerative disorder, which
severely impacts on the global economic development and healthcare system. Though AD …

Alzheimer disease (AD) is the most common form of age-related dementia. The etiology of
AD is considered to be multifactorial as only a negligible percentage of cases have a familial …

INTRODUCTION Globally, circadian clock–driven protein phosphorylation is a key
mechanism to temporally compartmentalize biological processes across the day in …

Studies of psychiatric disorders have traditionally focused on emotional symptoms such as
depression, anxiety and hallucinations. However, poorly controlled cognitive deficits are …

Fibrillar deposits of highly phosphorylated tau are a key pathological feature of several
neurodegenerative tauopathies including Alzheimer's disease (AD) and some …