Enhancer function underlies regulatory processes by which cells establish patterns of gene
expression. Recent results suggest that many enhancers are specified by particular …

The cohesin complex is a major constituent of interphase and mitotic chromosomes. Apart
from its role in mediating sister chromatid cohesion, it is also important for DNA double …

During cell division, transcription factors (TFs) are removed from chromatin twice, during
DNA synthesis and during condensation of chromosomes. How TFs can efficiently find their …

Current epigenomics approaches have facilitated the genome-wide identification of
regulatory elements based on chromatin features and transcriptional regulator binding and …

In most eukaryotic cells, fatty acid synthesis (FAS) occurs in the cytoplasm and in
mitochondria. However, the relative contribution of mitochondrial FAS (mtFAS) to the cellular …

Research in the fruit fly Drosophila melanogaster has led to insights in neural development,
axon guidance, ion channel function, synaptic transmission, learning and memory, diurnal …

Cohesin is a chromosome-associated multisubunit protein complex that is highly conserved
in eukaryotes and has close homologs in bacteria. Cohesin mediates cohesion between …

Cells allocate substantial resources toward monitoring levels of nutrients that can be used
for ATP generation by mitochondria. Among the many specialized cell types, neurons are …

Cohesin-mediated sister chromatid cohesion is essential for chromosome segregation and
post-replicative DNA repair,. In addition, evidence from model organisms,,, and from human …

Sister chromatid cohesion, which is essential for mitosis, is mediated by a multi-subunit
protein complex called cohesin. Cohesin's Scc1, Smc1 and Smc3 subunits form a tripartite …