The potential for microRNA therapeutics and clinical research

J Hanna, GS Hossain, J Kocerha - Frontiers in genetics, 2019 - frontiersin.org
As FDA-approved small RNA drugs start to enter clinical medicine, ongoing studies for the
microRNA (miRNA) class of small RNAs expand its preclinical and clinical research …

miRNAs reshape immunity and inflammatory responses in bacterial infection

X Zhou, X Li, M Wu - Signal transduction and targeted therapy, 2018 - nature.com
Pathogenic bacteria cause various infections worldwide, especially in immunocompromised
and other susceptible individuals, and are also associated with high infant mortality rates in …

The Role of microRNAs and Long Non-Coding RNAs in the Regulation of the Immune Response to Mycobacterium tuberculosis Infection

M Kundu, J Basu - Frontiers in immunology, 2021 - frontiersin.org
Non-coding RNAs have emerged as critical regulators of the immune response to infection.
MicroRNAs (miRNAs) are small non-coding RNAs which regulate host defense mechanisms …

MicroRNAs as immune regulators and biomarkers in tuberculosis

L Wang, Y Xiong, B Fu, D Guo, MY Zaky, X Lin… - Frontiers in …, 2022 - frontiersin.org
Tuberculosis (TB), which is caused by Mycobacterium tuberculosis (Mtb), is one of the most
lethal infectious disease worldwide, and it greatly affects human health. Some diagnostic …

Tuberculosis-associated microRNAs: from pathogenesis to disease biomarkers

A Sinigaglia, E Peta, S Riccetti, S Venkateswaran… - Cells, 2020 - mdpi.com
Tuberculosis (TB) caused by Mycobacterium tuberculosis is one of the most lethal infectious
diseases with estimates of approximately 1.4 million human deaths in 2018. M. tuberculosis …

miRNAs in immune responses to Mycobacterium tuberculosis infection

T Yang, B Ge - Cancer letters, 2018 - Elsevier
Tuberculosis (TB) is one of the most fatal infectious diseases, affecting one third of the
world's population. The causative agent, Mycobacterium tuberculosis (Mtb), has a well …

Silencing miR-125b-5p attenuates inflammatory response and apoptosis inhibition in mycobacterium tuberculosis-infected human macrophages by targeting DNA …

G Liu, Q Wan, J Li, X Hu, X Gu, S Xu - Cell Cycle, 2020 - Taylor & Francis
Tuberculosis is one of the most important infectious diseases worldwide and macrophage
apoptosis is the major host defense mechanism against TB. We attempted to characterize …

Non-coding RNAs in tuberculosis epidemiology: Platforms and approaches for investigating the genome's dark matter

A Almatroudi - International Journal of Molecular Sciences, 2022 - mdpi.com
A growing amount of information about the different types, functions, and roles played by
non-coding RNAs (ncRNAs) is becoming available, as more and more research is done …

MicroRNAs as diagnostic biomarkers for tuberculosis: a systematic review and meta-analysis

EA Daniel, B Sathiyamani, K Thiruvengadam… - Frontiers in …, 2022 - frontiersin.org
Background The early diagnosis of tuberculosis using novel non-sputum-based biomarkers
is of high priority in the End TB strategy. MicroRNAs (miRNAs) are significant regulators of …

Dysregulated circRNAs in plasma from active tuberculosis patients

Z Yi, K Gao, R Li, Y Fu - Journal of Cellular and Molecular …, 2018 - Wiley Online Library
Endogenous circular RNAs (circRNAs) have been reported in various diseases. However,
their role in active TB remains unknown. The study was aimed to determine plasma circRNA …