Next-generation pertussis vaccines based on the induction of protective T cells in the respiratory tract

CN Chasaide, KHG Mills - Vaccines, 2020 - mdpi.com
Immunization with current acellular pertussis (aP) vaccines protects against severe
pertussis, but immunity wanes rapidly after vaccination and these vaccines do not prevent …

Obesity and metabolic dysfunction drive sex-associated differential disease profiles in hACE2-mice challenged with SARS-CoV-2

KS Lee, BP Russ, TY Wong, AM Horspool, MT Winters… - IScience, 2022 - cell.com
Severe outcomes from SARS-CoV-2 infection are highly associated with preexisting
comorbid conditions like hypertension, diabetes, and obesity. We utilized the diet-induced …

Long-Term Analysis of Pertussis Vaccine Immunity to Identify Potential Markers of Vaccine-Induced Memory Associated With Whole Cell But Not Acellular Pertussis …

KL Weaver, CB Blackwood, AM Horspool… - Frontiers in …, 2022 - frontiersin.org
Over two decades ago acellular pertussis vaccines (aP) replaced whole cell pertussis
vaccines (wP) in several countries. Since then, a resurgence in pertussis has been …

Diet induced obesity and type 2 diabetes drives exacerbated sex-associated disease profiles in K18-hACE2-mice challenged with SARS-CoV-2

KS Lee, BP Russ, TY Wong, AM Horspool, MT Winters… - bioRxiv, 2022 - biorxiv.org
SARS-CoV-2 infection results in wide-ranging disease manifestation from asymptomatic to
potentially lethal. Infection poses an increased threat of severity to at-risk populations …

Long-term analysis of pertussis vaccine immunity uncovers a memory B cell response to whole cell pertussis immunization that is absent from acellular immunized …

KL Weaver, CB Blackwood, AM Horspool, GM Pyles… - bioRxiv, 2021 - biorxiv.org
Over two decades ago acellular pertussis vaccines (aP) replaced whole cell pertussis
vaccines (wP) in several countries. Since then, a resurgence in pertussis has been …