Dengue virus (DENV) is the etiological agent of dengue fever. Severe dengue could be fatal
and there is currently no effective antiviral agent or vaccine. The only licensed vaccine …

Chronic infection with hepatitis C virus (HCV) is a major cause of hepatocellular carcinoma
(HCC). Novel treatments with direct-acting antivirals achieve high rates of sustained …

The interferon-induced transmembrane (IFITM) family of proteins have recently been
identified as important host effector molecules of the type I interferon response against …

Signal transducer and activator of transcription 3 (STAT3) is a key regulator of numerous
physiological functions, including the immune response. As pathogens elicit an acute phase …

Signal transducer and activator of transcription 3 (STAT3) has a prominent role in mediating
resistance to conventional chemo-/radio-therapies and modern targeted drugs. While a …

Janus kinase (JAK) inhibitors have been developed as novel immunomodulatory drugs and
primarily used for treating rheumatoid arthritis and other inflammatory diseases. Recent …

RUNX1 overlapping RNA (RUNXOR) is a long non-coding RNA and plays a pivotal role in
the differentiation of myeloid cells via targeting runt-related transcription factor 1 (RUNX1) …

Human herpesvirus 8 (HHV-8) encodes four viral interferon regulatory factors (vIRFs) that
target cellular IRFs and/or other innate-immune and stress signaling regulators and …

Metabolism is a crucial frontier of host-virus interaction as viruses rely on their host cells to
provide nutrients and energy for propagation. Vaccinia virus (VACV) is the prototype …

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor which can
be activated by cytokines, growth factor receptors, and nonreceptor-like tyrosine kinase. An …