Cells are compartmentalized by numerous membrane-enclosed organelles and
membraneless compartments to ensure that a wide variety of cellular activities occur in a …

The ability of cells to divide asymmetrically is essential for generating diverse cell types
during development. The past 10 years have seen tremendous progress in our …

Genetic studies, using floral homeotic mutants, have led to the ABC model of flower
development. This model proposes that the combinatorial action of three sets of genes, the …

The tight junction is an intracellular junctional structure that mediates adhesion between
epithelial cells and is required for epithelial cell function. Tight junctions control paracellular …

Elongation of the body axis is accompanied by the assembly of a polarized cytoarchitecture
that provides the basis for directional cell behavior. We find that planar polarity in the …

Abstract PAR (partitioning-defective) proteins, which were first identified in the nematode
Caenorhabditis elegans, are essential for asymmetric cell division and polarized growth …

Virtually every aspect of cellular function within a metazoan organism, including proliferative
status, metabolism, gene expression, cytoskeletal organization, and indeed the cell's very …

Cell division is commonly thought to involve the equal distribution of cellular components
into the two daughter cells. During many cell divisions, however, proteins, membrane …

Stem and progenitor cells use asymmetric cell divisions to balance proliferation and
differentiation. Evidence from invertebrates shows that this process is regulated by proteins …

Cellular asymmetry is critical for the development of multicellular organisms. Here we show
that homologues of proteins necessary for asymmetric cell division in Caenorhabditis …