Since the advent of penicillin, the β-lactam antibiotics have been the subject of much
discussion and investigation within both the scientific and public sectors. β-Lactam …

In consequence of their biological effects, conformationally constrained carbocyclic β-amino
acids have generated great interest among synthetic and medicinal chemists in the past 2 …

1. Introduction....................................................................... 5832 2. Kinetic resolutions.....................
............................................ 5833 2.1. Enzymes acting on C–N bonds …

Desymmetrization of meso compounds to yield chiral products proved to be a powerful
synthetic tool in asymmetric synthesis since it allows formation of multiple stereogenic …

Chiral nitrogenated compounds are highly attractive compounds because of their
importance in agrochemicals, fine chemicals, and pharmaceuticals but also due to their …

Structures of several dozen of known antibacterial, antifungal or antiprotozoal agents are
based on the amino acid scaffold. In most of them, the amino acid skeleton is of a crucial …

This compendium focuses on functionalised sugar amino acids (SAAs) and their 3-to 6-
membered nitrogen heterocyclic and carbocyclic analogues. The main benefit of using SAAs …

Acquired immunodeficiency syndrome (AIDS) is caused by infection with the human
immunodeficiency virus (HIV). Although treatments against HIV infection are available, AIDS …

Hydrolytic enzymes, such as lactamases or hydantoinases, can be valuably applied to
convert lactams (cyclic amides) and cyclic imides into optically pure compounds, for …

Enantiopure β-amino acids 1a–4a and β-lactams 1b–4b were prepared simultaneously
through the lipolase-catalysed enantioselective ring opening of unsaturated racemic β …