Abstract Purpose of Review Articular chondrocytes are exclusively responsible for the
turnover of the extracellular matrix (ECM) of hyaline cartilage. However, chondrocytes are …

Primary cilia are microtubule‐based organelles that project from the cell surface to enable
transduction of various developmental signaling pathways. The process of intraflagellar …

Osteoarthritis is a chronic disease that can be initiated by altered joint loading or injury of the
cartilage. The mechanically sensitive PIEZO ion channels have been shown to transduce …

Objective Mechanical loading significantly influences the physiology and pathology of
articular cartilage, although the mechanisms of mechanical signal transduction are not fully …

Chondrocyte deformation, which occurs during mechanical loading, is thought to play an
important role in the mechano‐transduction pathway. In designing a scaffold that can be …

Intervertebral discs (IVD) have a higher extracellular osmolarity than most other tissues;
moreover their osmolarity changes by around 25% during each diurnal cycle. In this study …

Objective: Cartilage swelling is an early event in osteoarthritis (OA). However, the response
of chondrocytes to increased tissue hydration is unknown. This work studied the volume and …

OBJECTIVE: Mechanical stress above the physiological range can profoundly influence
articular cartilage causing matrix damage, changes to chondrocyte metabolism and cell …

Many cell types have significant negative resting membrane potentials (RMPs) resulting
from the activity of potassium‐selective and chloride‐selective ion channels. In excitable …

OBJECTIVE: The effects of mechanical deformation of intact cartilage tissue on chondrocyte
biosynthesis in situ have been well documented, but the mechanotransduction pathways …