Uterine fibroids are benign monoclonal neoplasms of the myometrium, representing the
most common tumors in women worldwide. To date, no long-term or noninvasive treatment …

Chronic lymphocytic leukemia (CLL) is an incurable B-cell neoplasm characterized by highly
variable clinical outcomes. In recent years, genomic and molecular studies revealed a …

Transcriptional dysregulation induced by disease‐defining genetic alterations of proteins in
transcriptional machinery is a key feature of cancers. Mediator complex subunit 12 (MED12) …

BIRC3 is monoallelically deleted in up to 80% of chronic lymphocytic leukemia (CLL) cases
harboring del (11q). In addition, truncating mutations in the remaining allele of this gene can …

Abstract Cyclin-dependent kinase 8 (CDK8) plays an momentous role in transcription
regulation by forming kinase module or transcription factor phosphorylation. A large number …

To identify genomic alterations contributing to the pathogenesis of high-risk chronic
lymphocytic leukemia (CLL) beyond the well-established role of TP53 aberrations, we …

Richter syndrome represents the evolution of chronic lymphocytic leukemia into an
aggressive tumor, most commonly diffuse large B-cell lymphoma. The lack of in vitro and in …

Simple Summary Mutations of the NOTCH1 gene are a validated prognostic marker in
chronic lymphocytic leukemia and a potential predictive marker for anti-CD20-based …

The Mediator complex is an essential coregulator of RNA polymerase II transcription. More
recent developments suggest Mediator functions as a link between transcription regulation …

Transcriptional dysregulation is central to many diseases including cancer. Mutation or
deregulated expression of proteins involved in transcriptional machinery leads to aberrant …