Genomic instability consists of a range of genetic alterations within the genome that
contributes to tumor heterogeneity and drug resistance. It is a well-established characteristic …

Gastric cancer (GC) is a highly aggressive malignancy that remains a significant contributor
to cancer-related mortality worldwide, despite a decline in incidence in recent years. Early …

When discussing chromosomal instability, most of the literature focuses on the
characterization of individual molecular mechanisms. These studies search for genomic and …

The SKP1, CUL1, F-box protein (SCF) complex encompasses a group of 69 SCF E3
ubiquitin ligase complexes that primarily modify protein substrates with poly-ubiquitin chains …

Ovarian cancers encompass a group of neoplasms originating from germinal tissues and
exhibiting distinct clinical, pathological, and molecular features. Among these, epithelial …

Aneuploidy is defined as the cellular state of having a number of chromosomes that deviates
from a multiple of the normal haploid chromosome number of a given organism. Aneuploidy …

Ovarian cancer is the most lethal gynecological malignancy. Recurrence and
chemoresistance are tough challenges leading to poor prognosis. HJURP is a molecular …

Objective High-grade serous ovarian cancer (HGSOC) is the most lethal gynaecological
malignancy in women with a high level of mortality, metastatic disease, disease recurrence …

Despite high-grade serous ovarian cancer (HGSOC) being the most common and lethal
gynecological cancer in women, the early etiological events driving disease development …

Proteolysis targeting chimeras (PROTAC) are an emerging precision medicine strategy,
which targets key proteins for proteolytic degradation to ultimately induce cancer cell killing …