Recent advancements and developments in search of anti-tuberculosis agents: a quinquennial update and future directions
Tuberculosis (TB) has been considered as the highly chronic, contagious and infectious
disorder caused by Mycobacterium tuberculosis (Mtb). Every year more than 10 million …
disorder caused by Mycobacterium tuberculosis (Mtb). Every year more than 10 million …
Design and synthesis of novel quinazolinone-pyrazole derivatives as potential α-glucosidase inhibitors: Structure-activity relationship, molecular modeling and kinetic …
In this study, a new series of quinazolinone-pyrazole hybrids were designed, synthesized
and screened for their α-glucosidase inhibitory activity. The results of the in vitro screening …
and screened for their α-glucosidase inhibitory activity. The results of the in vitro screening …
Comparative Metabolic Pathways Analysis and Subtractive Genomics Profiling to Prioritize Potential Drug Targets Against Streptococcus pneumoniae
Streptococcus pneumoniae is a notorious pathogen that affects∼ 450 million people
worldwide and causes up to four million deaths per annum. Despite availability of antibiotics …
worldwide and causes up to four million deaths per annum. Despite availability of antibiotics …
Design, synthesis and biological evaluation of benzo-[d]-imidazo-[2, 1-b]-thiazole and imidazo-[2, 1-b]-thiazole carboxamide triazole derivatives as antimycobacterial …
S Chitti, K Van Calster, D Cappoen, A Nandikolla… - RSC …, 2022 - pubs.rsc.org
In the search for new anti-mycobacterial agents, we revealed the importance of imidazo-[2, 1-
b]-thiazole and benzo-[d]-imidazo-[2, 1-b]-thiazole carboxamide derivatives. We designed, in …
b]-thiazole and benzo-[d]-imidazo-[2, 1-b]-thiazole carboxamide derivatives. We designed, in …
Identification of a Novel Therapeutic Target against XDR Salmonella Typhi H58 Using Genomics Driven Approach Followed Up by Natural Products Virtual Screening
Typhoid fever is caused by a pathogenic, rod-shaped, flagellated, and Gram-negative
bacterium known as Salmonella Typhi. It features a polysaccharide capsule that acts as a …
bacterium known as Salmonella Typhi. It features a polysaccharide capsule that acts as a …
Identification of the seaweed metabolites as potential anti-tubercular agents against human pantothenate synthetase: an in silico approach
MS Arokia Rajan, R Thirunavukkarasu, J Joseph… - Current …, 2023 - Springer
Tuberculosis is the disease which is caused due to the contagion of Mycobacterium
tuberculosis. The multidrug resistance Mycobacterium tuberculosis is the main hassle in the …
tuberculosis. The multidrug resistance Mycobacterium tuberculosis is the main hassle in the …
Ajoene: a natural compound with enhanced antimycobacterial and antibiofilm properties mediated by efflux pump modulation and ROS generation against M …
Tuberculosis (TB) continues to be a primary worldwide health concern due to relatively
ineffective treatments. The prolonged duration of conventional antibiotic therapy warrants …
ineffective treatments. The prolonged duration of conventional antibiotic therapy warrants …
Exploring optimal drug targets through subtractive proteomics analysis and pangenomic insights for tailored drug design in tuberculosis
Tuberculosis (TB), caused by Mycobacterium tuberculosis, ranks among the top causes of
global human mortality, as reported by the World Health Organization's 2022 TB report. The …
global human mortality, as reported by the World Health Organization's 2022 TB report. The …
New investigations with lupane type a-ring azepane triterpenoids for antimycobacterial drug candidate design
O Kazakova, R Racoviceanu, A Petrova… - International Journal of …, 2021 - mdpi.com
Twenty lupane type A-ring azepano-triterpenoids were synthesized from betulin and its
related derivatives and their antitubercular activity against Mycobacterium tuberculosis …
related derivatives and their antitubercular activity against Mycobacterium tuberculosis …
Mycobacterium tuberculosis: Pathogenesis and therapeutic targets
J Yang, L Zhang, W Qiao, Y Luo - MedComm, 2023 - Wiley Online Library
Tuberculosis (TB) remains a significant public health concern in the 21st century, especially
due to drug resistance, coinfection with diseases like immunodeficiency syndrome (AIDS) …
due to drug resistance, coinfection with diseases like immunodeficiency syndrome (AIDS) …