Glucose production and the consumption of high levels of carbohydrate increase the chance
of insulin resistance, especially in cases of obesity. Therefore, maintaining a balanced …

The Kinin B2 receptor (B2R) is classically involved in vasodilation and inflammatory
responses. However, through the observation of hypoglycemic effects of Angiotensin-I …

The oligopeptidase neurolysin (EC 3.4. 24.16; Nln) was first identified in rat brain synaptic
membranes and shown to ubiquitously participate in the catabolism of bioactive peptides …

Leptin's in vivo effect on the rodent skeleton depends on the model used and the mode of
administration. Superactive mouse leptin antagonist (SMLA) was produced and then …

Simple Summary Obesity is a significant health concern associated with fat accumulation
and complications like inflammation, cancer, and diabetes. Understanding its molecular …

Metabolic syndrome is a cluster of metabolic risk factors such as obesity, diabetes and
cardiovascular diseases. Mitochondria is the main site of ATP production and its dysfunction …

Given the importance of the kinin B1 receptor in insulin and leptin hormonal regulation,
which in turn is crucial in maternal adaptations to ensure nutrient supply to the fetus, we …

Over the last decade, the role of renin-angiotensin system (RAS) on the development of
obesity and its comorbidities has been extensively addressed. Both circulating and local …

Kinins B 1 and B 2 receptors (B 1 R and B 2 R) are classically associated with inflammation,
but our group has recently demonstrated new roles for B 1 R in metabolism using a knockout …

Cisplatin is a chemotherapeutic agent that causes severe renal dysfunction. The kinin B1
receptor has been associated with the migration of immune cells to injured tissue as well as …