Pax genes play key roles in the formation of tissues and organs during embryogenesis.
Pax3 and Pax7 mark myogenic progenitor cells and regulate their behavior and their entry …

PAX proteins function as transcription factors and play an essential role in organogenesis
during embryonic development in regulating cell proliferation and self-renewal, resistance to …

The growth and repair of skeletal muscle after birth depends on satellite cells that are
characterized by the expression of Pax7. We show that Pax3, the paralogue of Pax7, is also …

We describe here isolation and characterization of CD133+ cells derived from normal adult
human kidney. These cells lacked the expression of hematopoietic markers and expressed …

The efficient delivery of short interfering RNAs (siRNAs) into cells provides a powerful
approach to study cellular functions. SiRNAs were coupled to the membrane permeant …

Crosstalk between the oestrogen receptor (ER) and ERBB2/HER-2 pathways has long been
implicated in breast cancer aetiology and drug response, yet no direct connection at a …

Populations of self-renewing cells that arise during normal embryonic development harbour
the potential for rapid proliferation, migration or transdifferentiation and, therefore, tumour …

Tamoxifen, a selective oestrogen receptor modulator, has been used in the treatment of all
stages of hormone-responsive breast cancer. However, tamoxifen shows partial oestrogenic …

Cell-lineage-specific transcription factors are a group of regulatory proteins expressed in
embryonic, differentiated, or neoplastic cells of the same lineage and represent a valuable …

Endometrial cancer is the most common gynaecological cancer, and is associated with
endometrial hyperplasia, unopposed oestrogen exposure and adjuvant therapy for breast …