Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and implicates causal proteins for Alzheimer's disease

D Western, J Timsina, L Wang, C Wang, C Yang… - Nature Genetics, 2024 - nature.com
The integration of quantitative trait loci (QTLs) with disease genome-wide association
studies (GWASs) has proven successful in prioritizing candidate genes at disease …

Cell Adhesion Molecule Signaling at the Synapse: Beyond the Scaffold

B Verpoort, J de Wit - Cold Spring Harbor Perspectives …, 2024 - cshperspectives.cshlp.org
Synapses are specialized intercellular junctions connecting pre-and postsynaptic neurons
into functional neural circuits. Synaptic cell adhesion molecules (CAMs) constitute key …

Non-canonical interplay between glutamatergic NMDA and dopamine receptors shapes synaptogenesis

N Bénac, G Ezequiel Saraceno, C Butler… - Nature …, 2024 - nature.com
Direct interactions between receptors at the neuronal surface have long been proposed to
tune signaling cascades and neuronal communication in health and disease. Yet, the lack of …

[HTML][HTML] Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and informs causal proteins for Alzheimer's disease

C Cruchaga, D Western, J Timsina, L Wang… - Research …, 2023 - ncbi.nlm.nih.gov
The integration of quantitative trait loci (QTL) with disease genome-wide association studies
(GWAS) has proven successful at prioritizing candidate genes at disease-associated loci …

[HTML][HTML] VLK drives extracellular phosphorylation of EphB2 to govern the EphB2-NMDAR interaction and injury-induced pain

KD Srikanth, H Elahi, P Chander, HR Washburn… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Phosphorylation of hundreds of protein extracellular domains is mediated by two kinase
families, yet the significance of these kinases is underexplored. Here, we find that the …

Phosphorylation of Doc2 by EphB2 modulates Munc13-mediated SNARE complex assembly and neurotransmitter release

H Zhang, M Lei, Y Zhang, H Li, Z He, S Xie, L Zhu… - Science …, 2024 - science.org
At the synapse, presynaptic neurotransmitter release is tightly controlled by release
machinery, involving the soluble N-ethylmaleimide–sensitive factor attachment protein …

Unraveling the mysteries of dendritic spine dynamics: Five key principles shaping memory and cognition

H Kasai - Proceedings of the Japan Academy, Series B, 2023 - jstage.jst.go.jp
Recent research extends our understanding of brain processes beyond just action potentials
and chemical transmissions within neural circuits, emphasizing the mechanical forces …

[PDF][PDF] Review Unraveling the mysteries of dendritic spine dynamics: Five key principles shaping memory and cognition

H KASAI - 2023 - pdfs.semanticscholar.org
Recent research extends our understanding of brain processes beyond just action potentials
and chemical transmissions within neural circuits, emphasizing the mechanical forces …