Telomerase reverse transcriptase (TERT) is a catalytic subunit of telomerase. Telomerase
complex plays a key role in cancer formation by telomere dependent or independent …

There is an urgent need to identify novel therapies for childhood cancers. Neuroblastoma is
the most common pediatric solid tumor, and accounts for~ 15% of childhood cancer‐related …

Background Intratumoral heterogeneity is the primary challenge in the treatment of
glioblastoma (GBM). The presence of glioma stem cells (GSCs) and their conversion …

High-risk neuroblastoma (NB) is a significant clinical challenge. MYCN and Anaplastic
Lymphoma Kinase (ALK), which are often involved in high-risk NB, lead to increased …

High-risk neuroblastoma (NB) often involves MYCN amplification as well as mutations in
ALK. Currently, high-risk NB presents significant clinical challenges, and additional …

Cancers overcome replicative immortality by activating either telomerase or an alternative
lengthening of telomeres (ALT) mechanism. ALT occurs in~ 25% of high-risk …

A cardinal feature that distinguishes clinically high-risk neuroblastoma from low-risk tumors
is telomere maintenance. Specifically, neuroblastoma tumors with either active telomerase …

Peripheral neuroblastic tumors (neuroblastoma, ganglioneuroblastoma and
ganglioneuroma) are heterogeneous and their diverse and wide range of clinical behaviors …

Neuroblastoma is a common solid tumor in children and a leading cause of cancer death in
children. Neuroblastoma exhibits genetic, morphological, and clinical heterogeneity that …

The childhood malignancy neuroblastoma belongs to the group of embryonal tumors and
originates from progenitor cells of the sympathoadrenal lineage. Treatment options for …