Paralog dispensability shapes homozygous deletion patterns in tumor genomes
B De Kegel, CJ Ryan - Molecular Systems Biology, 2023 - embopress.org
Genomic instability is a hallmark of cancer, resulting in tumor genomes having large
numbers of genetic aberrations, including homozygous deletions of protein coding genes …
numbers of genetic aberrations, including homozygous deletions of protein coding genes …
Meta-analysis of dispensable essential genes and their interactions with bypass suppressors
C Pons, J van Leeuwen - Life Science Alliance, 2024 - life-science-alliance.org
Genes have been historically classified as essential or non-essential based on their
requirement for viability. However, genomic mutations can sometimes bypass the …
requirement for viability. However, genomic mutations can sometimes bypass the …