The sigma-1 (σ1) receptor, an enigmatic protein originally classified as an opioid receptor
subtype, is now understood to possess unique structural and functional features of its own …

A total of 29 novel quinazoline-2-aminothiazole hybrids containing a 4-piperidinylamide
linker were designed, synthesized, and evaluated for their anti-microbial properties against …

Sigma receptors are usually classified as a separate class of intracellular receptors. Among
them the sigma-1 receptor has been the most studied regarding its pharmacological …

Abstract The sigma-1 (σ 1) receptor is an endoplasmic reticulum (ER) chaperone protein,
enriched in mitochondria-associated membranes. Its activation triggers physiological …

The photoactivation of sulfonium salt EDA (electron donor-acceptor) complexes provides a
mild platform for aryl-radical-mediated halogen atom transfer activation of a wide range of …

Linear aromatic N-tricyclic compounds with promising antiviral activity and minimal
cytotoxicity were prepared and analyzed in the last years. Specifically, the pyrido [2, 3-g] …

A series of new piperidine-4-carbohydrazide derivatives bearing a quinazolinyl moiety were
prepared and evaluated for their fungicidal activities against agriculturally important fungi …

For more in-depth exploration of the chemical space around the entrance channel of HIV-1
reverse transcriptase (RT), a series of novel indolylarylsulfones (IASs) bearing different …

Background: Neurogenic agents emerge as innovative drugs for the treatment of Alzheimer's
disease (AD), whose pathological complexity suggests strengthening research in the multi …

σ1 and/or σ2 receptors play a crucial role in pathological conditions such as pain,
neurodegenerative disorders, and cancer. A set of spirocyclic cyclohexanes with diverse O …